ArticleThe EMBO journal1998
Evidence that the RdeA protein is a component of a multistep phosphorelay modulating rate of development in Dictyostelium.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling inCells · 2025Review
- Copine C plays a role in adhesion and streaming inCell adhesion & migration · 2024Article
- Derivatives of Differentiation-Inducing Factor 1 Differentially Control Chemotaxis and Stalk Cell Differentiation inBiology · 2023Article
- The physiological regulation of macropinocytosis duringJournal of cell science · 2018Article
- A critical-like collective state leads to long-range cell communication in Dictyostelium discoideum aggregation.PLoS biology · 2017Article
- Use of a Probabilistic Motif Search to Identify Histidine Phosphotransfer Domain-Containing Proteins.PloS one · 2016Article
- Article
- Genetic control of morphogenesis in Dictyostelium.Developmental biology · 2015Review
- Two-component histidine phosphotransfer protein Ypd1 is not essential for viability in Candida albicans.Eukaryotic cell · 2014Article
- Histidine phosphotransfer proteins in fungal two-component signal transduction pathways.Eukaryotic cell · 2013Review
- Crystal structure of histidine phosphotransfer protein ShpA, an essential regulator of stalk biogenesis in Caulobacter crescentus.Journal of molecular biology · 2009Article
- GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation development.BMC developmental biology · 2007Article
- Peptide signaling during terminal differentiation of Dictyostelium.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Genetic interactions of the E3 ubiquitin ligase component FbxA with cyclic AMP metabolism and a histidine kinase signaling pathway during Dictyostelium discoideum development.Eukaryotic cell · 2003Article
- Constitutively active protein kinase A disrupts motility and chemotaxis in Dictyostelium discoideum.Eukaryotic cell · 2003Article
- CulB, a putative ubiquitin ligase subunit, regulates prestalk cell differentiation and morphogenesis in Dictyostelium spp.Eukaryotic cell · 2002Article
- cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection.Journal of muscle research and cell motility · 2002Review
- A contextual framework for characterizing motility and chemotaxis mutants in Dictyostelium discoideum.Journal of muscle research and cell motility · 2002Review
- A model for cGMP signal transduction in Dictyostelium in perspective of 25 years of cGMP research.Journal of muscle research and cell motility · 2002Review
- Osmotic stress response in Dictyostelium is mediated by cAMP.The EMBO journal · 2000Article
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4 authors.
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Abstract
We have isolated an insertional mutant of Dictyostelium discoideum that aggregated rapidly and formed spores and stalk cells within 14 h of development instead of the normal 24 h. We have shown by parasexual genetics that the insertion is in the rdeA locus and have cloned the gene. It encodes a predicted 28 kDa protein (RdeA) that is enriched in charged residues and is very hydrophilic. Constructs with the DNA for the c-Myc epitope or for the green fluorescent protein indicate that RdeA is not compartmentalized. RdeA displays homology around a histidine residue at amino acid 65 with members of the H2 module family of phosphotransferases that participate in multistep phosphoryl relays. Replacement of this histidine rendered the protein inactive. The mutant is complemented by transformation with the Ypd1 gene of Saccharomyces cerevisiae, itself an H2 module protein. We propose that RdeA is part of a multistep phosphorelay system that modulates the rate of development.
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