ArticleThe EMBO journal1998
Functional properties of the ryanodine receptor type 3 (RyR3) Ca2+ release channel.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 120 citations in OpenAlex.
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- Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN.The Journal of cell biology · 2022Article
- Interferon-stimulated gene products as regulators of central carbon metabolism.The FEBS journal · 2021Article
- Article
- Elementary calcium signaling in arterial smooth muscle.Channels (Austin, Tex.) · 2019Review
- NO-sGC Pathway Modulates CaFrontiers in physiology · 2017Article
- Decoding calcium signaling across the nucleus.Physiology (Bethesda, Md.) · 2014Review
- Quercetin as a fluorescent probe for the ryanodine receptor activity in Jurkat cells.Pflugers Archiv : European journal of physiology · 2013Article
- Nucleoplasmic calcium signaling and cell proliferation: calcium signaling in the nucleus.Cell communication and signaling : CCS · 2013Article
- Functional classification of skeletal muscle networks. II. Applications to pathophysiology.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Ryanodine receptors.Skeletal muscle · 2011Article
- Redox modulation of diaphragm contractility: Interaction between DHPR and RyR channels.Free radical biology & medicine · 2010Article
- Role of ryanodine receptor subtypes in initiation and formation of calcium sparks in arterial smooth muscle: comparison with striated muscle.Journal of biomedicine & biotechnology · 2009Review
- Insect ryanodine receptors: molecular targets for novel pest control chemicals.Invertebrate neuroscience : IN · 2008Review
- Inactivation of Ca2+ transients in amphibian and mammalian muscle fibres.Journal of muscle research and cell motility · 2004Article
- Ca2+-dependent excitation-contraction coupling triggered by the heterologous cardiac/brain DHPR beta2a-subunit in skeletal myotubes.Biophysical journal · 2003Article
- Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms.Hepatology (Baltimore, Md.) · 2002Article
- Identification and function of ryanodine receptor subtype 3 in non-pregnant mouse myometrial cells.The Journal of physiology · 2002Article
- A novel Ca2+-induced Ca2+ release mechanism mediated by neither inositol trisphosphate nor ryanodine receptors.The Biochemical journal · 2002Article
- A novel cycling assay for cellular cADP-ribose with nanomolar sensitivity.The Biochemical journal · 2002Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Single-channel analysis of sarcoplasmic reticulum vesicles prepared from diaphragm muscle, which contains both RyR1 and RyR3 isoforms, revealed the presence of two functionally distinct ryanodine receptor calcium release channels. In addition to channels with properties typical of RyR1 channels, a second population of ryanodine-sensitive channels with properties distinct from those of RyR1 channels was observed. The novel channels displayed close-to-zero open-probability at nanomolar Ca2+ concentrations in the presence of 1 mM ATP, but were shifted to the open conformation by increasing Ca2+ to micromolar levels and were not inhibited at higher Ca2+ concentrations. These novel channels were sensitive to the stimulatory effects of cyclic adenosine 5'-diphosphoribose (cADPR). Detection of this second population of RyR channels in lipid bilayers was always associated with the presence of the RyR3 isoform in muscle preparations used for single-channel measurements and was abrogated by the knockout of the RyR3 gene in mice. Based on the above, we associated the novel population of channels with the RyR3 isoform of Ca2+ release channels. The functional properties of the RyR3 channels are in agreement with a potential qualitative contribution of this channel to Ca2+ release in skeletal muscle and in other tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.