ArticleThe Biochemical journal1997
14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor.
Article in The Biochemical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 98 citations in OpenAlex.
- 14-3-3β is essential for milk composition stimulated by Leu/IGF-1 via IGF1R signaling pathway in BMECs.In vitro cellular & developmental biology. Animal · 2022Article
- Intelligent Design of 14-3-3 Docking Proteins Utilizing Synthetic Evolution Artificial Intelligence (SYN-AI).ACS omega · 2019Article
- Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling.Journal of neuroendocrinology · 2016Article
- Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation.Cellular and molecular life sciences : CMLS · 2014Review
- Molecular Signatures of Recurrent Hepatocellular Carcinoma Secondary to Hepatitis C Virus following Liver Transplantation.Journal of transplantation · 2013Article
- Effects of somatic mutations in the C-terminus of insulin-like growth factor 1 receptor on activity and signaling.Journal of signal transduction · 2012Article
- Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances.Frontiers in endocrinology · 2012Article
- 14-3-3 phosphoprotein interaction networks - does isoform diversity present functional interaction specification?Frontiers in plant science · 2012Article
- The insulin receptor: a new target for cancer therapy.Frontiers in endocrinology · 2011Article
- IGF-IR in neuroprotection and brain tumors.Frontiers in bioscience (Landmark edition) · 2009Review
- IGF and insulin receptor signaling in breast cancer.Journal of mammary gland biology and neoplasia · 2008Article
- The role of stratifin in fibroblast-keratinocyte interaction.Molecular and cellular biochemistry · 2007Review
- Article
- Proteomic identification of 14-3-3zeta as an adapter for IGF-1 and Akt/GSK-3beta signaling and survival of renal mesangial cells.International journal of biological sciences · 2006Article
- Adaptation of the Ras-recruitment system to the analysis of interactions between membrane-associated proteins.Nucleic acids research · 2003Article
- 14-3-3 proteins; bringing new definitions to scaffolding.Oncogene · 2001Review
- The role of the insulin receptor substrate-1 in the differentiation of rat hippocampal neuronal cells.Oncogene · 2001Article
- A novel approach for the identification of protein-protein interaction with integral membrane proteins.Nucleic acids research · 2001Article
- Review
- 14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor.The Biochemical journal · 2000Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used a yeast two-hybrid system to identify proteins which bind to the cytosolic portion of the type 1 insulin-like growth factor (IGF) receptor (IGFIR) but not the insulin receptor (IR). This analysis identified 14-3-3beta and zeta proteins. 14-3-3beta also binds to the IGFIR but not the IR in vitro and 14-3-3-IGFIR complexes are present in insect cells overexpressing the IGFIR cytoplasmic domain. 14-3-3 proteins are substrates of the IGFIR in the yeast system and in vitro. The interaction of 14-3-3 with the IGFIR requires receptor-kinase activity and maps to the C-terminus of the receptor, but does not depend on tyrosine residues in this or the juxtamembrane regions. Instead, the binding maps to serine residue 1283 and requires phosphorylation of this residue. 14-3-3 proteins are phosphoserine-binding proteins which have been shown to interact directly with components of the mitogenic and apoptotic signalling pathways, suggesting that they participate in growth regulation. Our findings suggest that 14-3-3 proteins may play a role in IGFIR signal transduction and may contribute to the differences in IGF and IR signalling capabilities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.