ArticleThe Biochemical journal1997
Identification of cytoskeleton-associated proteins in isolated rat liver endosomes.
Article in The Biochemical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 73 citations in OpenAlex.
- The temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells.BMC biology · 2024Article
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- Annexin A6 regulates interleukin-2-mediated T-cell proliferation.Immunology and cell biology · 2016Article
- Annexins as organizers of cholesterol- and sphingomyelin-enriched membrane microdomains in Niemann-Pick type C disease.Cellular and molecular life sciences : CMLS · 2012Review
- ERK1/2 and p38 MAPKs are complementarily involved in estradiol 17ß-D-glucuronide-induced cholestasis: crosstalk with cPKC and PI3K.PloS one · 2012Article
- Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function.Molecular biology of the cell · 2011Article
- Plasmon-resonant nanoparticles and nanostars with magnetic cores: synthesis and magnetomotive imaging.ACS nano · 2010Article
- Annexin A6-induced alterations in cholesterol transport and caveolin export from the Golgi complex.Traffic (Copenhagen, Denmark) · 2007Article
- CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling.Molecular biology of the cell · 2005Article
- Structure of human annexin a6 at the air-water interface and in a membrane-bound state.Biophysical journal · 2004Article
- Microtubule-dependent movement of late endocytic vesicles in vitro: requirements for Dynein and Kinesin.Molecular biology of the cell · 2004Article
- The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin.Molecular biology of the cell · 2004Article
- An in vivo Method for Determination of Endosomal Distribution of Both Ligand and Asialoglycoprotein Receptor in Rat Liver.Comparative hepatology · 2004Article
- Nuclear annexin II negatively regulates growth of LNCaP cells and substitution of ser 11 and 25 to glu prevents nucleo-cytoplasmic shuttling of annexin II.BMC biochemistry · 2003Article
- Annexin II expression is reduced or lost in prostate cancer cells and its re-expression inhibits prostate cancer cell migration.Oncogene · 2003Article
- A balance of KIF1A-like kinesin and dynein organizes early endosomes in the fungus Ustilago maydis.The EMBO journal · 2002Article
- Pharmacodynamics and pharmacogenomics of diverse receptor-mediated effects of methylprednisolone in rats using microarray analysis.Journal of pharmacokinetics and pharmacodynamics · 2002Article
- VP40, the matrix protein of Marburg virus, is associated with membranes of the late endosomal compartment.Journal of virology · 2002Article
- Microtubule and motor-dependent endocytic vesicle sorting in vitro.The Journal of cell biology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The polypeptides of three highly purified endosomal fractions isolated from the livers of oestradiol-treated rats were analysed by Western blotting, and the amount and distribution of intrinsic and cytoskeletal-associated proteins were quantified and studied. The 'late' endosomes [multivesicular bodies (MVBs)] had the lowest content of cytoskeletal-associated proteins, the most significant being the presence of 25% of the total dynein found in endosomes. The 'early' endosome [compartment of uncoupling receptors and ligands (CURL)] fraction contained kinesin (40% of the total in endosomes), dynein (23%), actin (15%) and tubulin (10%). The receptor-recycling compartment (RRC), also demonstrated to be involved in transcytosis, contained the largest number and enrichment of cytoskeletal proteins: actin (84% of the total in endosomes), alpha-actinin (90%), dynein (52%), tubulin (91%) and kinesin (45%). We also analysed and compared the presence of different endosomal markers such as Rab4, Rab5 and cellubrevin (vesicle soluble NSF attachment protein receptor) in CURL (41%, 15% and 60%) and in RRC (44%, 75% and 30% respectively). Finally, the expression of annexins I, II, IV and VI was studied: annexin I was equally distributed between MVBs and CURL; annexin II was highly enriched in RRC (95%), annexin IV was equally distributed between CURL and RRC, and annexin VI was enriched in CURL (57%). The results indicate that isolated rat liver endosomes contain all the required molecular machinery for the achievement of their role in intracellular trafficking.
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