ArticleNucleic acids research1998
Oligoribonucleotide circularization by 'template-mediated' ligation with T4 RNA ligase: synthesis of circular hammerhead ribozymes.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Emerging strategies and innovations in circular RNA synthesis.Molecular therapy. Nucleic acids · 2026Review
- Synthesis of Ultra-Large Fibrous Proteins from Bacteria via a Looped-Translation System.bioRxiv : the preprint server for biology · 2026Article
- The therapeutic potential of circular RNAs.Nature reviews. Genetics · 2025Review
- Circular RNAs: Novel Players in Cancer Mechanisms and Therapeutic Strategies.International journal of molecular sciences · 2024Review
- Review
- Circular RNA vaccine in disease prevention and treatment.Signal transduction and targeted therapy · 2023Review
- Pros and Cons of In Vitro Methods for Circular RNA Preparation.International journal of molecular sciences · 2022Review
- Phospho-RNA sequencing with circAID-p-seq.Nucleic acids research · 2022Article
- The design and synthesis of circular RNAs.Methods (San Diego, Calif.) · 2021Review
- Circular RNA: BiosynthesisFrontiers in bioengineering and biotechnology · 2021Review
- Preferential production of RNA rings by T4 RNA ligase 2 without any splint through rational design of precursor strand.Nucleic acids research · 2020Article
- In vitro circularization of RNA.RNA biology · 2017Review
- RNA circularization strategies in vivo and in vitro.Nucleic acids research · 2015Review
- Identification and remediation of biases in the activity of RNA ligases in small-RNA deep sequencing.Nucleic acids research · 2011Article
- miR-ID: a novel, circularization-based platform for detection of microRNAs.RNA (New York, N.Y.) · 2011Article
- Discovery and characterization of a thermostable bacteriophage RNA ligase homologous to T4 RNA ligase 1.Nucleic acids research · 2003Article
- Addition of non-genomically encoded nucleotides to the 3'-terminus of maize mitochondrial mRNAs: truncated rps12 mRNAs frequently terminate with CCA.Nucleic acids research · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Circular hammerhead ribozymes were synthesized from linear oligoribonucleotides using T4 RNA ligase. Some of the precursors could not be efficiently circularized under standard conditions. For these molecules, the use of a DNA template allowed their efficient circularization. The template was designed to prevent the precursor from folding into an unsuitable structure. The template allowed circular ribozymes as small as 15 nucleotides in length to be efficiently synthesized at concentrations as high as 50 microM in the ligation reaction. The circular products retained their biological activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.