ArticleJournal of epidemiology and community health1998
Is immunising all patients with chronic lung disease in the community against influenza cost effective? Evidence from a general practice based clinical prospective cohort study in Utrecht, The Netherlands.
Article in Journal of epidemiology and community health, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Vaccines for preventing influenza in the elderly.The Cochrane database of systematic reviews · 2018Pooled it
- Pneumococcal vaccines for preventing pneumonia in chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2017Pooled it
- The effect of cold temperature on increased exacerbation of chronic obstructive pulmonary disease: a nationwide study.PloS one · 2013Trial
- Interpretation of the Key Issues of Expert Consensus on Immunomodulatory Therapies for Chronic Obstructive Pulmonary Disease.Journal of translational internal medicine · 2022Article
- Routine primary care data for scientific research, quality of care programs and educational purposes: the Julius General Practitioners' Network (JGPN).BMC health services research · 2018Article
- Prevention of COPD exacerbations: medications and other controversies.ERJ open research · 2015Review
- What is the role of virus vaccination in patients with asthma?Current allergy and asthma reports · 2007Review
- Bacterial lysate in the prevention of acute exacerbation of COPD and in respiratory recurrent infections.International journal of chronic obstructive pulmonary disease · 2007Article
- Pharmacological treatment of chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2006Review
- [New therapeutic approaches to COPD].Der Internist · 2004Article
- Walking exercise in patients with intermittent claudication. Experience in routine clinical practice.The British journal of general practice : the journal of the Royal College of General Practitioners · 2004Article
- Influenza.Lancet (London, England) · 2003Review
- Conventional influenza vaccination is not associated with complications in working-age patients with asthma or chronic obstructive pulmonary disease.American journal of epidemiology · 2003Article
- Review
- Confounding by indication in non-experimental evaluation of vaccine effectiveness: the example of prevention of influenza complications.Journal of epidemiology and community health · 2002Review
- A model to estimate the cost benefit of an occupational vaccination programme for influenza with Influvac in the UK.PharmacoEconomics · 2002Article
- Influenza vaccinations: who needs them and when?Drugs · 2002Review
- Pharmacoeconomics of influenza vaccination in the elderly: reviewing the available evidence.Drugs & aging · 2000Review
- The Saudi Thoracic Society Evidence-based guidelines for the diagnosis and management of chronic obstructive pulmonary disease.Annals of thoracic medicineArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectiveThere is little information on the potential benefit of immunising all patients with chronic lung disease in the community against influenza. The clinical effectiveness and economic benefit was established of the influenza vaccination programme in a general practice based cohort of adult patients with chronic lung disease followed up during the 1995/96 influenza A epidemic.
designA prospective cohort study from October 1995 to March 1996.
settingThe study was undertaken in the Utrecht General Practices Network with six large group practices, covering a total population of approximately 50,000 patients in the Netherlands. PATIENTS: Computerised medical records of 1696 patients with chronic lung disease aged over 18 years with an indication for vaccination according to the Dutch GP guidelines were reviewed. MAIN
resultsThe overall attack rate of any complication, including all cause death, low respiratory tract infection, and acute cardiac disease was 15%. Exacerbations of lung disease were most frequent (13%). Death, pneumonia, and acute cardiac disease were mainly limited to patients > or = 65 years. No effectiveness of the immunisation programme could be established in patients 18-64 years (n = 1066), after controlling for baseline prognosis in multivariable logistic regression analysis. In vaccinees > or = 65 years (n = 630), the occurrence of any complication was reduced by 50% (95% CI 17, 70%). The economic benefit was estimated at 50 Pounds per elderly vaccinee.
conclusionsThis study suggests that in the Netherlands immunisation of elderly patients with chronic lung disease against influenza is effective and cost-saving, hence these patients should be given high priority. More, preferably experimental, studies are needed to establish whether adult lung patients under 65 years in the community will also benefit from vaccination.
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