ArticleGut1998
Increased immunoglobulin G production by short term cultured duodenal biopsy samples from HIV infected patients.
Article in Gut, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Intestinal barrier dysfunction mediates Whipple's disease immune reconstitution inflammatory syndrome (IRIS).Immunity, inflammation and disease · 2022Article
- Gut Microbiome Homeostasis and the CD4 T- Follicular Helper Cell IgA Axis in Human Immunodeficiency Virus Infection.Frontiers in immunology · 2021Review
- Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon.Mucosal immunology · 2018Article
- Architectural and functional alterations of the small intestinal mucosa in classical Whipple's disease.Mucosal immunology · 2017Article
- CXCR4/IgG-expressing plasma cells are associated with human gastrointestinal tissue inflammation.The Journal of allergy and clinical immunology · 2014Article
- Default in plasma and intestinal IgA responses during acute infection by simian immunodeficiency virus.Retrovirology · 2012Article
- Intraepithelial γδ T cells remain increased in the duodenum of AIDS patients despite antiretroviral treatment.PloS one · 2012Article
- Specific and nonspecific B-cell function in the small intestines of patients with Whipple's disease.Infection and immunity · 2010Article
- Intestinal B cell hyperactivity in AIDS is controlled by highly active antiretroviral therapy.Gut · 2004Article
- Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSecretory immunity is a major defence mechanism against infections at mucosal surfaces which are common in HIV infected patients.
aimsTo analyse intestinal immunoglobulin production in HIV infection in comparison with that in saliva and serum. PATIENTS AND
methodsImmunoglobulin G (IgG), A (IgA), and M (IgM) concentrations were determined in supernatants of short term cultured duodenal biopsy samples, serum, and saliva from HIV infected patients (n = 28) and controls (n = 14) by radial immunodiffusion.
resultsIgG was increased in the supernatants of short term cultured biopsy samples and saliva from HIV infected patients compared with controls (p < 0.01), but IgA and IgM levels were normal. In contrast, both IgG and IgA concentrations in serum were higher in HIV infected patients than in controls (p < 0.002). No correlation was found between IgA produced by duodenal biopsy specimens and serum IgA.
conclusionAbnormalities in mucosal immunoglobulin production in HIV infection were surprisingly small, indicating that specific secretory immunity rather than quantitative immunoglobulin production may be impaired. However, increased production of IgG could contribute to mucosal inflammation by complement activation. Our findings of normal mucosal IgA production and the lack of correlation between serum and mucosal IgA argues against an intestinal origin for the increased serum IgA levels in HIV infected patients.
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