ArticleProceedings of the National Academy of Sciences of the United States of America1998
Host cell dependence of viral morphology.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 143 citations in OpenAlex.
- Article
- Molecular architecture of Influenza A virions.bioRxiv : the preprint server for biology · 2026Article
- Implications of morphological variation in influenza viruses.Microbiology and molecular biology reviews : MMBR · 2025Review
- Influenza filaments: a graveyard of postdocs no longer?The EMBO journal · 2025Article
- The hidden impact of producer cells on virion composition and infectivity.Future virology · 2025Article
- The Identification and Function of Linc01615 on Influenza Virus Infection and Antiviral Response.International journal of molecular sciences · 2024Article
- Biomimetic and bioinspired nano-platforms for cancer vaccine development.Exploration (Beijing, China) · 2023Review
- A Virus Is a Community: Diversity within Negative-Sense RNA Virus Populations.Microbiology and molecular biology reviews : MMBR · 2022Review
- Biomedical nanoparticle design: What we can learn from viruses.Journal of controlled release : official journal of the Controlled Release Society · 2021Review
- Respiratory syncytial virus: from pathogenesis to potential therapeutic strategies.International journal of biological sciences · 2021Review
- Comprehensive Characterization of Transcriptional Activity during Influenza A Virus Infection Reveals Biases in Cap-Snatching of Host RNA Sequences.Journal of virology · 2020Article
- Single-particle measurements of filamentous influenza virions reveal damage induced by freezing.The Journal of general virology · 2019Article
- Super-resolution microscopy reveals significant impact of M2e-specific monoclonal antibodies on influenza A virus filament formation at the host cell surface.Scientific reports · 2019Article
- Review
- Article
- The Morphology and Assembly of Respiratory Syncytial Virus Revealed by Cryo-Electron Tomography.Viruses · 2018Article
- Intracellular Colocalization of Influenza Viral RNA and Rab11A Is Dependent upon Microtubule Filaments.Journal of virology · 2017Article
- Filamentous Influenza Viruses.Current clinical microbiology reports · 2016Article
- Protein-lipid interactions critical to replication of the influenza A virus.FEBS letters · 2016Review
- Lipid rafts both in cellular membrane and viral envelope are critical for PRRSV efficient infection.Virology · 2015Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The morphology of influenza virions was found to depend on cellular determinants. Influenza viral filaments up to 30 microm in length were observed to form at high levels on surfaces of various polarized epithelial cell types infected with the A/Udorn/72 virus. In contrast, virions produced by nonpolarized cell types infected with this virus were almost exclusively of spherical morphology. Disruption of the actin microfilament array by cytochalasin D treatment of polarized MDCK cells had a profound effect on viral morphology. Although virus titers and release of spherical particles were not reduced in the presence of cytochalasin D, we observed a 15-fold reduction in the release of filamentous particles. In contrast, the ratio of filaments to spheres produced by infected MDCK cells was not altered by the microtubule-disrupting agent nocodazole. These observations indicate that the polarized cell phenotype and the integrity of the actin microfilament network are important cellular determinants of the morphology of a filamentous influenza virus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.