ArticleProceedings of the National Academy of Sciences of the United States of America1998
Dopamine-induced recruitment of dopamine D1 receptors to the plasma membrane.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 113 citations in OpenAlex.
- Localization, trafficking, and signaling of trace amine-associated receptor 2 in mouse neuroblastoma cells.Cellular signalling · 2026Article
- Review
- The Dopamine DHypertension (Dallas, Tex. : 1979) · 2019Article
- Evidence for a regulated CaJournal of cell science · 2019Article
- Spatial encoding of GPCR signaling in the nervous system.Current opinion in cell biology · 2019Review
- Gene Expression Studies and Targeted Metabolomics Reveal Disturbed Serine, Methionine, and Tyrosine Metabolism in Early Hypertensive Nephrosclerosis.Kidney international reports · 2019Article
- Superoxide via Sp3 mechanism increases renal renin activity, renal AT1 receptor function, and blood pressure in rats.American journal of physiology. Renal physiology · 2018Article
- Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure.Cell reports · 2017Article
- Melamine induces CaAmerican journal of physiology. Cell physiology · 2017Article
- Dopamine regulates renal osmoregulation during hyposaline stress via DRD1 in the spotted scat (Scatophagus argus).Scientific reports · 2016Article
- Molecular Pharmacology of δ-Opioid Receptors.Pharmacological reviews · 2016Review
- GABAB receptor cell-surface export is controlled by an endoplasmic reticulum gatekeeper.Molecular psychiatry · 2016Article
- Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies.British journal of pharmacology · 2014Article
- Chaperoning G protein-coupled receptors: from cell biology to therapeutics.Endocrine reviews · 2014Review
- The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport.Kidney international · 2014Article
- Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and β-arrestin 1 pathway.Cell reports · 2013Article
- Human kidney-2 cells harbor functional dopamine D1 receptors that require Giα for Gq/11α signaling.American journal of physiology. Renal physiology · 2013Article
- Role of angiotensin AT(2) receptors in natriuresis: Intrarenal mechanisms and therapeutic potential.Clinical and experimental pharmacology & physiology · 2013Review
- Novel role of sorting nexin 5 in renal D(1) dopamine receptor trafficking and function: implications for hypertension.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- The intrarenal renin-angiotensin and dopaminergic systems: control of renal sodium excretion and blood pressure.Hypertension (Dallas, Tex. : 1979) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The recruitment of G protein-coupled receptors from the cytoplasm to the plasma membrane generally is believed to be a constitutive process. We show here by the use of both confocal microscopy and subcellular fractionation that, for at least one such receptor, this recruitment is regulated and not constitutive. Cells from a proximal tubular-like cell line, LLCPK1 cells, were incubated with either a D1 agonist, a dopamine precursor, or an inhibitor of dopamine metabolism to increase dopamine availability in the cell. Each of the three procedures led to a rapid translocation of dopamine D1 receptors from the cytosol to the plasma membrane.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.