ArticleThe Journal of physiology1998
The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neurones.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 103 citations in OpenAlex.
- Endogenous forms of ATP-ATPProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Activation of Intra-nodose Ganglion P2X7 Receptors Elicit Increases in Neuronal Activity.Cellular and molecular neurobiology · 2023Article
- Role of opioid receptors in modulation of P2X receptor-mediated cardiac sympathoexcitatory reflex response.Scientific reports · 2019Article
- Morphology of P2X3-immunoreactive nerve endings in the rat laryngeal mucosa.Histochemistry and cell biology · 2016Article
- Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X₁, P2X₂, P2X₃ channels, P2Y and A₃ metabotropic receptors in neurotransmission.Neuropharmacology · 2015Article
- Heteromeric assembly of P2X subunits.Frontiers in cellular neuroscience · 2013Review
- Expression of P2X(2) and P2X (3) receptors in the rat carotid sinus, aortic arch, vena cava, and heart, as well as petrosal and nodose ganglia.Purinergic signalling · 2012Article
- P2X and NMDA receptor involvement in temporomandibular joint-evoked reflex activity in rat jaw muscles.Brain research · 2010Article
- Understanding inflammatory pain: ion channels contributing to acute and chronic nociception.Pflugers Archiv : European journal of physiology · 2010Review
- Deletion of P2X3 receptors blunts gastro-oesophageal sensation in mice.Neurogastroenterology and motility · 2009Article
- Distribution of P2X(3) receptor immunoreactivity in myenteric ganglia of the mouse esophagus.Histochemistry and cell biology · 2009Article
- P2X3 receptor involvement in pain states.Molecular neurobiology · 2007Review
- Pharmacology of P2X channels.Pflugers Archiv : European journal of physiology · 2006Review
- Molecular properties of P2X receptors.Pflugers Archiv : European journal of physiology · 2006Review
- P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP.The Journal of physiology · 2005Article
- Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Agonist-dependence of recovery from desensitization of P2X(3) receptors provides a novel and sensitive approach for their rapid up or downregulation.British journal of pharmacology · 2004Article
- P2X3 receptors and peripheral pain mechanisms.The Journal of physiology · 2004Review
- Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Mechanotransduction by intraganglionic laminar endings of vagal tension receptors in the guinea-pig oesophagus.The Journal of physiology · 2003Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Whole-cell recordings were made from rat nodose ganglion neurones in culture and from human embryonic kidney (HEK293) cells stably transfected to express P2X2, P2X3 or both receptor subunits. We examined the blocking actions of 2',3'-O-trinitrophenyl-ATP (TNP-ATP) on currents evoked by the agonists ATP and alpha, beta-methylene ATP. 2. In cells expressing only P2X2 or P2X3 receptor subunits, the inhibition by TNP-ATP was fitted by a single binding site model with half-maximal concentrations of about 3 microM and 3 nM, respectively. In cells expressing both P2X2 and P2X3 receptor subunits, currents showed little or no desensitization, thus excluding contributions from homomeric P2X3 receptors. When alpha,beta-methylene ATP was the agonist (activating heteromeric P2X2/3 receptors), the inhibition by TNP-ATP conformed to a single binding site (half-maximal concentration about 3 nM). When ATP (30 microM) was the agonist, activating both heteromeric P2X2/3 as well as homomeric P2X2 receptors, the inhibition curve was biphasic (half-maximal concentrations about 3 nM and 3 microM); the proportion of high affinity sites in all six cells tested was about 40 %. 3. In nodose ganglion neurones, the inhibition by TNP-ATP of currents evoked by ATP (30 microM) was also clearly biphasic. In this case, individual neurones showed more variability in the proportion of high and low affinity sites for TNP-ATP. 4. We conclude that more than one form of multimeric P2X receptor channels are functionally expressed on the cell bodies of individual nodose ganglion neurones. On the basis of sensitivity to TNP-ATP, and other properties, one of these may correspond to the homomeric P2X2 receptor and the other(s) to heteromeric P2X2/3 receptors.
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