ArticleThe Journal of physiology1998
Multiple modulatory effects of dopamine on calcium channel kinetics in adult rat sensory neurons.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
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- Reverse-engineered models reveal differential membrane properties of autonomic and cutaneous unmyelinated fibers.PLoS computational biology · 2024Article
- The hypothalamic-spinal dopaminergic system: a target for pain modulation.Neural regeneration research · 2019Review
- Presynaptic Inhibition of Primary Nociceptive Signals to Dorsal Horn Lamina I Neurons by Dopamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Not All Predictions Are Equal: "What" and "When" Predictions Modulate Activity in Auditory Cortex through Different Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Dopamine modulation of transient receptor potential vanilloid type 1 (TRPV1) receptor in dorsal root ganglia neurons.The Journal of physiology · 2016Article
- Inhibition of tetrodotoxin-resistant sodium current in dorsal root ganglia neurons mediated by D1/D5 dopamine receptors.Molecular pain · 2013Article
- Monoaminergic modulation of spinal viscero-sympathetic function in the neonatal mouse thoracic spinal cord.PloS one · 2012Article
- Conversion of the modulatory actions of dopamine on spinal reflexes from depression to facilitation in D3 receptor knock-out mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Differential effects of CB1 and opioid agonists on two populations of adult rat dorsal root ganglion neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Direct and remote modulation of L-channels in chromaffin cells: distinct actions on alpha1C and alpha1D subunits?Molecular neurobiology · 2004Review
- Changes in extracellular Ca2+ can affect the pattern of discharge in rat thalamic neurons.The Journal of physiology · 2001Article
- Direct autocrine inhibition and cAMP-dependent potentiation of single L-type Ca2+ channels in bovine chromaffin cells.The Journal of physiology · 2001Article
- A neurocomputational theory of the dopaminergic modulation of working memory functions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The aim of this research was to study the modulatory effects induced on high-voltage-activated (HVA) calcium channels and pharmacologically isolated subtypes through dopamine receptor activation. 2. The experiments were carried out on acutely isolated adult rat sensory neurons, recorded by means of the whole-cell patch-clamp technique. 3. At saturating concentrations dopamine was effective in inducing: (a) a voltage-dependent prolongation of activation kinetics, (b) a voltage-independent scaling down of the currents without any changes in activation and inactivation kinetics, and (c) an acceleration of inactivation kinetics, not affected by a positive conditioning prepulse. 4. These three inhibitory effects were observed on N- and P/Q-type currents, whereas only a voltage-independent scaling up and/or scaling down was observed on L-type current. 5. The inhibitory effects were sometimes observed in isolation in different neurons, but more frequently they were variously combined in the same cell. A correlation analysis of these effects shows no relationship between them, corroborating the conclusion that they are mechanistically distinct. 6. The existence of an inactivating effect accounts for the occurrence of a voltage-dependent inhibitory effect in some cells without an apparent slowing down of activation kinetics, since the increased inactivation may mask the slow component of the activation. 7. The multiple modulatory effects on calcium channels, even on pharmacologically separated N-, L- and P/Q-currents, suggest that pharmacological and functional classifications do not necessarily match completely. 8. The multiple modulatory effects on HVA calcium currents may play a prominent role both in controlling the integrative properties of neurons and in regulating output at a presynaptic level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.