ArticleThe Journal of physiology1998
KATP channel formation by the sulphonylurea receptors SUR1 with Kir6.2 subunits in rat dorsal vagal neurons in situ.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 80 citations in OpenAlex.
- AMPK-mediated potentiation of GABAergic signalling drives hypoglycaemia-provoked spike-wave seizures.Brain : a journal of neurology · 2022Article
- The surprising complexity of KATP channel biology and of genetic diseases.The Journal of clinical investigation · 2020Article
- Brain Glucose-Sensing Mechanism and Energy Homeostasis.Molecular neurobiology · 2019Review
- Physiology of Astroglia.Advances in experimental medicine and biology · 2019Review
- Modulation of Excitability of Stellate Neurons in the Ventral Cochlear Nucleus of Mice by ATP-Sensitive Potassium Channels.The Journal of membrane biology · 2018Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- Central Role of Maladapted Astrocytic Plasticity in Ischemic Brain Edema Formation.Frontiers in cellular neuroscience · 2016Review
- Ion Channels in Obesity: Pathophysiology and Potential Therapeutic Targets.Frontiers in pharmacology · 2016Review
- KATP Channels in the Cardiovascular System.Physiological reviews · 2016Review
- Does nutrient sensing determine how we "see" food?Current diabetes reports · 2015Review
- Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Multiplicity of effectors of the cardioprotective agent, diazoxide.Pharmacology & therapeutics · 2013Review
- Ion channels in the central regulation of energy and glucose homeostasis.Frontiers in neuroscience · 2013Article
- Modulation of gastrointestinal vagal neurocircuits by hyperglycemia.Frontiers in neuroscience · 2013Article
- Characterization of an ATP-sensitive K(+) channel in rat carotid body glomus cells.Respiratory physiology & neurobiology · 2011Article
- Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Sulfonylurea receptor 1 subunits of ATP-sensitive potassium channels and myocardial ischemia/reperfusion injury.Trends in cardiovascular medicine · 2009Review
- Article
- Neuronal responses to transient hypoglycaemia in the dorsal vagal complex of the rat brainstem.The Journal of physiology · 2006Article
- Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+.Biophysical journal · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Functional and molecular properties of ATP-sensitive K+ (KATP) channels were studied in dorsal vagal neurons (DVNs) of rat brainstem slices using patch-clamp and single-cell antisense RNA amplification-polymerase chain reaction (PCR) techniques. 2. In the cell-attached configuration, 1 mM cyanide resulted in block of spontaneous firing and concomitant opening of single channels with a mean single open time of 2-3 ms and a burst duration of up to several hundred milliseconds. Inhibition of such single-channel activity with 200 microM tolbutamide led to the reappearance of spontaneous discharge. 3. Whole-cell recordings during anoxia revealed a hyperpolarization of the DVNs. Harvesting of cytoplasm, antisense RNA amplification and subsequent PCR showed coexpression for single DVNs of mRNA for the sulphonylurea receptor SUR1 isoform and for the inwardly rectifying K+ channel subunit Kir6.2, but not for the SUR2 or Kir6.1 isoforms of these channel/receptor subclasses. 4. Upon anoxia, a stable depolarization by less than 10 mV was observed in non-excitable cells in the dorsal vagal nucleus. These cells, which expressed glial fibrillary acidic protein (GFAP), showed a high level of mRNA for Kir6.2, a weak signal for SUR1, whereas SUR2 or Kir6.1 were not detected. 5. The results suggest that functional KATP channels in DVNs are constituted by the formation of Kir6.2 subunits with SUR1 receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.