ArticleJournal of virology1998
In vivo distribution of the human immunodeficiency virus/simian immunodeficiency virus coreceptors: CXCR4, CCR3, and CCR5.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 197 citations in OpenAlex.
- Role of CCL5 and CCR5 gene polymorphisms in epidermal growth factor receptor signalling blockade in metastatic colorectal cancer: analysis of the FIRE-3 trial.European journal of cancer (Oxford, England : 1990) · 2019Trial
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- Diaphragm and lubricant gel for prevention of HIV acquisition in southern African women: a randomised controlled trial.Lancet (London, England) · 2007Trial
- Biological and mutational analyses of CXCR4-antagonist interactions and design of new antagonistic analogs.Bioscience reports · 2023Article
- HIV Associated Neurodegenerative Disorders: A New Perspective on the Role of Lipid Rafts in Gp120-Mediated Neurotoxicity.Current HIV research · 2018Review
- Rectal microbicide development.Current topics in microbiology and immunology · 2014Review
- BLT humanized mice as model to study HIV vaginal transmission.The Journal of infectious diseases · 2013Review
- Comprehensive assessment of HIV target cells in the distal human gut suggests increasing HIV susceptibility toward the anus.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice.Retrovirology · 2012Article
- Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women.The open AIDS journal · 2012Article
- Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitro.Retrovirology · 2011Article
- In situ distribution of HIV-binding CCR5 and C-type lectin receptors in the human endocervical mucosa.PloS one · 2011Article
- Dimeric 2G12 as a potent protection against HIV-1.PLoS pathogens · 2010Article
- Exacerbation of facial motoneuron loss after facial nerve axotomy in CCR3-deficient mice.ASN neuro · 2009Article
- Human immunodeficiency virus type 1 V1-to-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection.Journal of virology · 2009Article
- Pertussis toxin signals through the TCR to initiate cross-desensitization of the chemokine receptor CXCR4.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- HIV infection of the genital mucosa in women.Current HIV/AIDS reports · 2009Review
- Adherence to diaphragm use for infection prevention: a prospective study of female sex workers in Kenya.Infectious diseases in obstetrics and gynecology · 2009Article
- Setting the stage: host invasion by HIV.Nature reviews. Immunology · 2008Review
- Improving defences at the portal of HIV entry: mucosal and innate immunity.PLoS medicine · 2008Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
We have evaluated the in vivo distribution of the major human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) coreceptors, CXCR4, CCR3, and CCR5, in both rhesus macaques and humans. T lymphocytes and macrophages in both lymphoid and nonlymphoid tissues are the major cell populations expressing HIV/SIV coreceptors, reaffirming that these cells are the major targets of HIV/SIV infection in vivo. In lymphoid tissues such as the lymph node and the thymus, approximately 1 to 10% of the T lymphocytes and macrophages are coreceptor positive. However, coreceptor expression was not detected on follicular dendritic cells (FDC) in lymph nodes, suggesting that the ability of FDC to trap extracellular virions is unlikely to be mediated by a coreceptor-specific mechanism. In the thymus, a large number of immature and mature T lymphocytes express CXCR4, which may render these cells susceptible to infection by syncytium-inducing viral variants that use this coreceptor for entry. In addition, various degrees of coreceptor expression are found among different tissues and also among different cells within the same tissues. Coreceptor-positive cells are more frequently identified in the colon than in the rectum and more frequently identified in the cervix than in the vagina, suggesting that the expression levels of coreceptors are differentially regulated at different anatomic sites. Furthermore, extremely high levels of CXCR4 and CCR3 expression are found on the neurons from both the central and peripheral nervous systems. These findings may be helpful in understanding certain aspects of HIV and SIV pathogenesis and transmission.
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