ArticleJournal of virology1998
Transcription factor YY1 represses cell-free replication from human papillomavirus origins.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Viral Interplay with the Host Sumoylation System.Advances in experimental medicine and biology · 2017Review
- Cellular transcription factor YY1 mediates the varicella-zoster virus (VZV) IE62 transcriptional activation.Virology · 2014Article
- Regulation of the varicella-zoster virus ORF3 promoter by cellular and viral factors.Virology · 2013Article
- An Sp1/Sp3 site in the downstream region of varicella-zoster virus (VZV) oriS influences origin-dependent DNA replication and flanking gene transcription and is important for VZV replication in vitro and in human skin.Journal of virology · 2012Article
- Construction of a full transcription map of human papillomavirus type 18 during productive viral infection.Journal of virology · 2011Article
- Article
- Cellular transcription factors Sp1 and Sp3 suppress varicella-zoster virus origin-dependent DNA replication.Journal of virology · 2008Article
- Functional mapping of the human papillomavirus type 16 E1 cistron.Journal of virology · 2008Article
- Modification of papillomavirus E2 proteins by the small ubiquitin-like modifier family members (SUMOs).Virology · 2008Article
- Replication and partitioning of papillomavirus genomes.Advances in virus research · 2008Review
- Human papillomavirus (HPV) origin-binding protein associates with mitotic spindles to enable viral DNA partitioning.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The papillomavirus E8-E2C protein represses DNA replication from extrachromosomal origins.Molecular and cellular biology · 2003Article
- Article
- The Papillomavirus E2 protein binds to and synergizes with C/EBP factors involved in keratinocyte differentiation.Journal of virology · 2003Article
- Cooperative activation of human papillomavirus type 8 gene expression by the E2 protein and the cellular coactivator p300.Journal of virology · 2002Article
- Yin yang 1 negatively regulates the differentiation-specific E1 promoter of human papillomavirus type 6.Journal of virology · 2000Article
- Productive replication of adeno-associated virus can occur in human papillomavirus type 16 (HPV-16) episome-containing keratinocytes and is augmented by the HPV-16 E2 protein.Journal of virology · 2000Article
- The hinge of the human papillomavirus type 11 E2 protein contains major determinants for nuclear localization and nuclear matrix association.Journal of virology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have established cell-free replication for the human papillomavirus type 18 (HPV-18) origin of replication (ori)-containing DNA by using purified HPV-18 E1 and E2 gene products expressed as fusion proteins in Escherichia coli. The transcription factor YY1 has been shown to regulate RNA transcription by binding to a sequence overlapping the putative E1 protein binding site in the HPV-18 ori. We show that exogenously added YY1 fusion protein inhibited HPV-18 ori replication. Cotransfection of YY1 expression vectors also inhibited transient replication in 293 cells. However, inhibition did not appear to be mediated by binding to its cognate site in the ori as YY1 also inhibited the replication of the HPV-11 ori, which does not have a known or suspected YY1 binding site. Moreover, inhibition was not alleviated by the inclusion of YY1 binding oligonucleotides in the replication reaction mixtures. Rather, we demonstrated a direct interaction between purified fusion E2 protein and fusion YY1 protein by the pull-down assay and a partial restoration of replication activity by an elevated E2 protein concentration. These results suggest that YY1 can inhibit HPV ori replication by interfering with E2 protein functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.