ArticleJournal of bacteriology1998
An rRNA fragment and its antisense can alter decoding of genetic information.
Article in Journal of bacteriology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Prevalence of small base-pairing RNAs derived from diverse genomic loci.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020Review
- The Ribosome as a Missing Link in Prebiotic Evolution III: Over-Representation of tRNA- and rRNA-Like Sequences and Plieofunctionality of Ribosome-Related Molecules Argues for the Evolution of Primitive Genomes from Ribosomal RNA Modules.International journal of molecular sciences · 2019Article
- Sources and Functions of Extracellular Small RNAs in Human Circulation.Annual review of nutrition · 2016Review
- Mutational eidence for a functional connection between two domains of 23S rRNA in translation termination.Journal of bacteriology · 2002Article
- Mutations in the GTPase center of Escherichia coli 23S rRNA indicate release factor 2-interactive sites.Journal of bacteriology · 2002Article
- A mechanism for stop codon recognition by the ribosome: a bioinformatic approach.RNA (New York, N.Y.) · 2001Article
- Covariance of complementary rRNA loop nucleotides does not necessarily represent functional pseudoknot formation in vivo.Journal of bacteriology · 2000Article
- Suppression of nonsense mutations induced by expression of an RNA complementary to a conserved segment of 23S rRNA.Journal of bacteriology · 1999Article
- Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis.RNA (New York, N.Y.) · 1999Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
rRNA plays a central role in protein synthesis and is intimately involved in the initiation, elongation, and termination stages of translation. However, the mode of its participation in these reactions, particularly as to the decoding of genetic information, remains elusive. In this paper, we describe a new approach that allowed us to identify an rRNA segment whose function is likely to be related to translation termination. By screening an expression library of random rRNA fragments, we identified a fragment of the Escherichia coli 23S rRNA (nucleotides 74 to 136) whose expression caused readthrough of UGA nonsense mutations in certain codon contexts in vivo. The antisense RNA fragment produced a similar effect, but in neither case was readthrough of UAA or UAG observed. Since termination at UGA in E. coli specifically requires release factor 2 (RF2), our data suggest that the fragments interfere with RF2-dependent termination.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.