ArticleInfection and immunity1998
Gammadelta+ T cells preferentially respond to live rather than killed malaria parasites.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans.PLoS pathogens · 2011Trial
- Immunity beyond borders: non-lethalFrontiers in immunology · 2026Article
- Human unconventional T cells in Plasmodium falciparum infection.Seminars in immunopathology · 2020Review
- Article
- Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life.Scientific reports · 2018Article
- γδ T Cells in Antimalarial Immunity: New Insights Into Their Diverse Functions in Protection and Tolerance.Frontiers in immunology · 2018Review
- A Unique Subset of γδ T Cells Expands and Produces IL-10 in Patients with Naturally Acquired Immunity against Falciparum Malaria.Frontiers in microbiology · 2017Article
- NK Cells: Uncertain Allies against Malaria.Frontiers in immunology · 2017Review
- Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate Vγ9Vδ2 T Cells.Infection and immunity · 2015Article
- Information use and plasticity in the reproductive decisions of malaria parasites.Malaria journal · 2014Article
- Strain variation in early innate cytokine induction by Plasmodium falciparum.Parasite immunology · 2010Article
- Effect of nutrient deficiencies on in vitro Th1 and Th2 cytokine response of peripheral blood mononuclear cells to Plasmodium falciparum infection.Malaria journal · 2010Article
- Innate immunity to malaria.Nature reviews. Immunology · 2004Review
- The war between the malaria parasite and the immune system: immunity, immunoregulation and immunopathology.Clinical and experimental immunology · 2003Review
- Optimal tumor necrosis factor induction by Plasmodium falciparum requires the highly localized release of parasite products.Infection and immunity · 2003Article
- Changes in cytokine production associated with acquired immunity to Plasmodium falciparum malaria.Clinical and experimental immunology · 2001Article
- Differential induction of cellular responses by live and dead Leishmania promastigotes in healthy donors.Clinical and experimental immunology · 2001Article
- Cellular basis of early cytokine response to Plasmodium falciparum.Infection and immunity · 2001Article
- Metabolic routes as targets for immunological discrimination of host and parasite.Infection and immunity · 2000Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have compared the in vitro responses of peripheral blood T cells from malaria-unexposed donors to live Plasmodium falciparum schizonts, freeze-thawed schizont extracts (P. falciparum schizont extracts [PfSE]), and parasite culture supernatants. We show that the cells responding to PfSE and parasite culture supernatants are predominantly CD4+ TCR alphabeta+ while in the presence of live schizonts there is an additional activation of TCR gammadelta+ cells. Activation of TCR gammadelta+ cells in response to PfSE was seen only when irradiated autologous feeder cells or recombinant interleukin-2 (IL-2) was added to the cultures. Live schizonts but not PfSE induced significant IL-2 production in vitro in the first 5 days after stimulation, suggesting that induction of early IL-2 by live parasites may contribute to the marked activation of the TCR gammadelta+ population.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.