ArticleInfection and immunity1998
Disruption of the cellular inflammatory response to Listeria monocytogenes infection in mice with disruptions in targeted genes.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host.Reviews in medical virology · 2026Review
- From Host Defense to Metabolic Signatures: Unveiling the Role of γδ T Cells in Bacterial Infections.Biomolecules · 2024Review
- Is the oral microbiome a source to enhance mucosal immunity against infectious diseases?NPJ vaccines · 2021Review
- Gamma Delta T Cells and Their Pathogenic Role in Psoriasis.Frontiers in immunology · 2021Review
- Role of Innate T Cells in Anti-Bacterial Immunity.Frontiers in immunology · 2015Review
- γδ T cells and their potential for immunotherapy.International journal of biological sciences · 2014Review
- Review
- Disparate host immunity to Mycobacterium avium subsp. paratuberculosis antigens in calves inoculated with M. avium subsp. paratuberculosis, M. avium subsp. avium, M. kansasii, and M. bovis.Clinical and vaccine immunology : CVI · 2013Article
- Vγ4+ T cells regulate host immune response to West Nile virus infection.FEMS immunology and medical microbiology · 2011Article
- Resolution of allergic airway inflammation and airway hyperreactivity is mediated by IL-17-producing {gamma}{delta}T cells.American journal of respiratory and critical care medicine · 2010Article
- Dysregulated chemokine receptor expression and chemokine-mediated cell trafficking in pediatric patients with ESRD.Clinical journal of the American Society of Nephrology : CJASN · 2008Article
- Monocyte-mediated defense against microbial pathogens.Annual review of immunology · 2008Review
- The chemokine system in arteriogenesis and hind limb ischemia.Journal of vascular surgery · 2007Review
- gammadelta T lymphocytes-selectable cells within the innate system?Journal of clinical immunology · 2007Review
- Vaccinia virus inhibits T cell receptor-dependent responses by human gammadelta T cells.The Journal of infectious diseases · 2007Article
- A defective Th1 response of the spleen in the initial phase may explain why splenectomy helps prevent a Listeria infection.Clinical and experimental immunology · 2005Article
- Chemokine receptor 5 is dispensable for innate and adaptive immune responses to Listeria monocytogenes infection.Infection and immunity · 2004Article
- Listeria monocytogenes mutants that fail to compartmentalize listerolysin O activity are cytotoxic, avirulent, and unable to evade host extracellular defenses.Infection and immunity · 2003Article
- Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.The Journal of clinical investigation · 2003Article
- Exaggerated proinflammatory and Th1 responses in the absence of gamma/delta T cells after infection with Listeria monocytogenes.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The results of this study to dissect the nature of the acquired immune response to infection with Listeria monocytogenes in mice with targetted gene disruptions show that successful resolution of disease requires the essential presence of alphabeta T cells and the capacity to elaborate gamma interferon. In the absence of either of these entities, mice experience increasingly severe hepatitis and tissue necrosis and die within a few days. The data from this study support the hypothesis that the protective process is the efficient replacement of neutrophils in lesions by longer-lived mononuclear phagocytes; alphabeta-T-cell-knockout mice died from progressive infection before neutrophil replacement could occur, whereas in gammadelta-T-cell-knockout mice this replacement process in the liver has previously been shown to be much slower. In the present study we attribute this delay to reduced production of the macrophage-attracting chemokine MCP-1 in the gammadelta-T-cell-knockout animals. These data further support the hypothesis that gammadelta T cells are important in controlling the inflammatory process rather than being essential to the expression of protection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.