ArticleNeurochemical research1998
Chronic lithium treatment decreases brain phospholipase A2 activity.
Article in Neurochemical research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 83 citations in OpenAlex.
- Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities.International journal of molecular sciences · 2021Review
- Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration.Metabolic brain disease · 2017Article
- Long-Term Lithium Treatment Increases cPLA₂ and iPLA₂ Activity in Cultured Cortical and Hippocampal Neurons.Molecules (Basel, Switzerland) · 2015Article
- Potential application of lithium in Parkinson's and other neurodegenerative diseases.Frontiers in neuroscience · 2015Review
- Effects of lithium on inflammation.ACS chemical neuroscience · 2014Review
- Chronic lithium feeding reduces upregulated brain arachidonic acid metabolism in HIV-1 transgenic rat.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans.Brain research bulletin · 2012Review
- Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects.Neuropsychobiology · 2010Review
- Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder.Psychiatry research · 2008Article
- In Vitro Interaction of Lithium on Phospholipids in Human Erythrocytes.Toxicology mechanisms and methods · 2008Article
- Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers.Molecular psychiatry · 2004Review
- Psychoses and creativity: is the missing link a biological mechanism related to phospholipids turnover?Prostaglandins, leukotrienes, and essential fatty acids · 2003Article
- Mood stabilizer psychopharmacology.Clinical neuroscience research · 2002Article
- Chronic lithium downregulates cyclooxygenase-2 activity and prostaglandin E(2) concentration in rat brain.Molecular psychiatry · 2002Article
- Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression.Molecular psychiatry · 2000Review
- In vivo fatty acid incorporation into brain phospholipids in relation to signal transduction and membrane remodeling.Neurochemical research · 1999Review
- Dynamics of docosahexaenoic acid metabolism in the central nervous system: lack of effect of chronic lithium treatment.Neurochemical research · 1999Article
- Manoalide, a phospholipase A2 inhibitor, inhibits arachidonate incorporation and turnover in brain phospholipids of the awake rat.Neurochemical research · 1998Article
- In vivo fatty acid incorporation into brain phosholipids in relation to plasma availability, signal transduction and membrane remodeling.Journal of molecular neuroscience : MNReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic lithium administration decreases the turnover of arachidonic acid (AA) in several brain phospholipids. This suggests that lithium may attenuate phospholipase A2 (PLA2) activity in brain. We now report effects of chronic lithium treatment on PLA2 activity in postnuclear supernatant from rat brain: Enzyme activity was determined by two assay methods, radiometric and fluorometric, and measured the release of the fatty acid on the second acyl position (sn2) from choline and ethanolamine phospholipids. PLA2 activity in brain postnuclear supernatant from rats chronically treated with lithium in the diet was significantly decreased (20-50%) when compared with controls. In vehicle or lithium-treated rats, PLA2 activity was not significantly augmented or attenuated by the addition of calcium chelators, divalent cations or LiCl supplementation (1.0 mM) to postnuclear supernatant. These results suggest that a major therapeutic effect of lithium is to attenuate brain PLA2 activity involved in signal transduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.