Trial reportNeurochemical research1998
Platelet MAO-B activity and serotonin content in patients with dementia: effect of age, medication, and disease.
Trial report in Neurochemical research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 32 citations in OpenAlex.
- Development and evaluation of a novel deuterated fluorine-18 PET tracer for MAO-B imaging.American journal of nuclear medicine and molecular imaging · 2026Article
- Characterization of neuroinflammatory positron emission tomography biomarkers in chronic traumatic encephalopathy.Brain communications · 2022Article
- Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities.International journal of molecular sciences · 2020Review
- Does patchouli oil change blood platelet monoamine oxidase-A activity of adult mammals?The journal of physiological sciences : JPS · 2018Article
- Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer's disease.Frontiers in cellular neuroscience · 2015Review
- Platelets, a reliable source for peripheral Alzheimer's disease biomarkers?Acta neuropathologica communications · 2014Review
- Platelet monoamine oxidase-A activity and aging: effect of carnosine.The journal of physiological sciences : JPS · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed at determining the effect of drug therapy, age and type of dementia on biological markers. Both platelet monoamine oxidase type B (MAO-B) activity and serotonin content of 57 demented patients and 20 control subjects were determined. Platelet MAO-B activity was measured using [14C]tyramine as substrate. Serotonin content was determined by HPLC-EC method. Increased platelet serotonin content and platelet count was found in patients with dementia compared to controls. A positive correlation was experienced between platelet MAO-B activity, platelet serotonin content and age. Platelet MAO-B activity was higher in the haloperidol treated group, compared with patients treated with anxyolitics. The main original finding of the present study is that platelet serotonin content is increased in demented patients with delusions compared to dementia without complications (p = 0.006). It seems, that platelet MAO-B activity is influenced mainly by drug therapy, while serotonin content rather reflects clinical characteristics in dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.