ArticleMolecular biology of the cell1998
Lumenal and transmembrane domains play a role in sorting type I membrane proteins on endocytic pathways.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex.Developmental cell · 2012Article
- Rab9-dependent retrograde transport and endosomal sorting of the endopeptidase furin.Journal of cell science · 2011Article
- S655 phosphorylation enhances APP secretory traffic.Molecular and cellular biochemistry · 2009Article
- Modulation of host cell endocytosis by the type III cytotoxin, Pseudomonas ExoS.Traffic (Copenhagen, Denmark) · 2008Article
- Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomes.Traffic (Copenhagen, Denmark) · 2006Article
- Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.Molecular biology of the cell · 2005Article
- Two motifs target Batten disease protein CLN3 to lysosomes in transfected nonneuronal and neuronal cells.Molecular biology of the cell · 2004Article
- The p55 tumour necrosis factor receptor TNFR1 contains a trans-Golgi network localization signal in the C-terminal region of its cytoplasmic tail.The Biochemical journal · 2002Article
- Lysosome-associated protein transmembrane 4 alpha (LAPTM4 alpha) requires two tandemly arranged tyrosine-based signals for sorting to lysosomes.The Biochemical journal · 2002Article
- Role of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomes.Molecular biology of the cell · 2002Article
- Endolyn is a mucin-like type I membrane protein targeted to lysosomes by its cytoplasmic tail.The Biochemical journal · 2000Article
- The Rous sarcoma virus Env glycoprotein contains a highly conserved motif homologous to tyrosine-based endocytosis signals and displays an unusual internalization phenotype.Molecular and cellular biology · 2000Article
- MAL, an integral element of the apical sorting machinery, is an itinerant protein that cycles between the trans-Golgi network and the plasma membrane.Molecular biology of the cell · 1999Article
- Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120.The Biochemical journal · 1998Article
- Efficient trafficking of TGN38 from the endosome to the trans-Golgi network requires a free hydroxyl group at position 331 in the cytosolic domain.Molecular biology of the cell · 1998Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that when the cytosolic domains of the type I membrane proteins TGN38 and lysosomal glycoprotein 120 (lgp120) are added to a variety of reporter molecules, the resultant chimeric molecules are localized to the trans-Golgi network (TGN) and to lysosomes, respectively. In the present study we expressed chimeric constructs of rat TGN38 and rat lgp120 in HeLa cells. We found that targeting information in the cytosolic domain of TGN38 could be overridden by the presence of the lumenal and transmembrane domains of lgp120. In contrast, the presence of the transmembrane and cytosolic domains of TGN38 was sufficient to deliver the lumenal domain of lgp120 to the trans-Golgi network. On the basis of steady-state localization of the various chimeras and antibody uptake experiments, we propose that there is a hierarchy of targeting information in each molecule contributing to sorting within the endocytic pathway. The lumenal and cytosolic domains of lgp120 contribute to sorting and delivery to lysosomes, whereas the transmembrane and cytosolic domains of TGN38 contribute to sorting and delivery to the trans-Golgi network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.