ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Structural features determining differential receptor regulation of neuronal Ca channels.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Regulation of Ca(V)2 calcium channels by G protein coupled receptors.Biochimica et biophysica acta · 2013Review
- In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor.Journal of psychopharmacology (Oxford, England) · 2013Article
- Inhibition of synaptic transmission and G protein modulation by synthetic CaV2.2 Ca²+ channel peptides.The Journal of physiology · 2011Article
- Low-voltage-activated ("T-Type") calcium channels in review.Journal of bioenergetics and biomembranes · 2003Review
- Neurotransmitter modulation of neuronal calcium channels.Journal of bioenergetics and biomembranes · 2003Review
- The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells.The Journal of physiology · 2003Article
- Increased expression of alpha 1A Ca2+ channel currents arising from expanded trinucleotide repeats in spinocerebellar ataxia type 6.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Attenuation of G protein-mediated inhibition of N-type calcium currents by expression of caveolins in mammalian NG108-15 cells.The Journal of physiology · 2001Article
- The C terminus of the Ca channel alpha1B subunit mediates selective inhibition by G-protein-coupled receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Control of gating mode by a single amino acid residue in transmembrane segment IS3 of the N-type Ca2+ channel.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- G-protein inhibition of N- and P/Q-type calcium channels: distinctive elementary mechanisms and their functional impact.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Selective regulation of N-type Ca channels by different combinations of G-protein beta/gamma subunits and RGS proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Interaction between G proteins and accessory subunits in the regulation of 1B calcium channels in Xenopus oocytes.The Journal of physiology · 2000Article
- The polyglutamine expansion in spinocerebellar ataxia type 6 causes a beta subunit-specific enhanced activation of P/Q-type calcium channels in Xenopus oocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Identification of residues in the N terminus of alpha1B critical for inhibition of the voltage-dependent calcium channel by Gbeta gamma.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- G protein modulation of CaV2 voltage-gated calcium channels.Channels (Austin, Tex.)Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Dihydropyridine-insensitive Ca channels are subject to direct receptor G-protein-mediated inhibition to differing extents. alpha1B channels are much more strongly modulated than alpha1E channels. To understand the structural basis for this difference, we have constructed and expressed various alpha1B and alpha1E chimeric Ca channels and examined their regulation by kappa-opioid receptors. Replacement of the first membrane-spanning domain of alpha1E with the corresponding region of alpha1B resulted in a chimeric Ca channel that was modulated by kappa-opioid receptors to a significantly greater extent than alpha1E. Transfer of the N terminus and I/II loop from alpha1B in addition to domain I resulted in a chimeric channel that was modulated to the same extent as alpha1B. Other regions of the molecule do not appear to contribute significantly to the degree of inhibition obtained, although the C terminus may contribute to facilitation.
Indexed as
Identifiers
9570799PMC6793165What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.