ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Galanin receptor-mediated inhibition of glutamate release in the arcuate nucleus of the hypothalamus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 82 citations in OpenAlex.
- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
- Preferential Gs protein coupling of the galanin GalPharmacological research · 2022Article
- The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior.Frontiers in molecular neuroscience · 2022Review
- The Lateral Hypothalamus: An Uncharted Territory for Processing Peripheral Neurogenic Inflammation.Frontiers in neuroscience · 2020Review
- Local cholinergic-GABAergic circuitry within the basal forebrain is modulated by galanin.Brain structure & function · 2017Article
- Galanin Activates G Protein Gated Inwardly Rectifying Potassium Channels and Suppresses Kisspeptin-10 Activation of GnRH Neurons.Endocrinology · 2016Article
- NPR-9, a Galanin-Like G-Protein Coupled Receptor, and GLR-1 Regulate Interneuronal Circuitry Underlying Multisensory Integration of Environmental Cues in Caenorhabditis elegans.PLoS genetics · 2016Article
- Glutamatergic Mechanisms Associated with Seizures and Epilepsy.Cold Spring Harbor perspectives in medicine · 2015Review
- Leptin acts via lateral hypothalamic area neurotensin neurons to inhibit orexin neurons by multiple GABA-independent mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors.Brain research · 2010Review
- Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation.Neurobiology of learning and memory · 2009Article
- Bidirectional regulation of stress responses by galanin in mice: involvement of galanin receptor subtype 1.Neuroscience · 2009Article
- Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice.Psychopharmacology · 2009Article
- The role of the neuropeptide galanin in forming type-specific behavioral characteristics.Neuroscience and behavioral physiology · 2008Article
- Galanin and its receptors in neurological disorders.Neuromolecular medicine · 2005Review
- Galanin acts as a neuroprotective factor to the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- AMPA-sst2 somatostatin receptor interaction in rat hypothalamus requires activation of NMDA and/or metabotropic glutamate receptors and depends on intracellular calcium.The Journal of physiology · 2003Article
- Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Pre- and postsynaptic actions of opioid and orphan opioid agonists in the rat arcuate nucleus and ventromedial hypothalamus in vitro.The Journal of physiology · 1999Article
- Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
It is thought that galanin, a 29 amino acid neuropeptide, is involved in various neuronal functions, including the regulation of food intake and hormone release. Consistent with this idea, galanin receptors have been demonstrated throughout the brain, with high levels being observed in the hypothalamus. However, little is known about the mechanisms by which galanin elicits its actions in the brain. Therefore, we studied the effects of galanin and its analogs on synaptic transmission using an in vitro slice preparation of rat hypothalamus. In arcuate nucleus neurons, application of galanin resulted in an inhibition of evoked glutamatergic EPSCs and a decrease in paired-pulse depression, indicating a presynaptic action. The fragments galanin 1-16 and 1-15 produced a robust depression of synaptic transmission, whereas the fragment 3-29 produced a lesser degree of depression. The chimeric peptides C7, M15, M32, and M40, which have been reported to antagonize some actions of galanin, all produced varying degrees of depression of evoked EPSCs. In a minority of cases, C7, M15, and M40 antagonized the actions of galanin. Analysis of mEPSCs in the presence of TTX and Cd2+, or after application of alpha-latrotoxin, indicated a site of action for galanin downstream of Ca2+ entry. Thus, our data suggest that galanin acts via several subtypes of presynaptic receptors to depress synaptic transmission in the rat arcuate nucleus.
Indexed as
Identifiers
9570780PMC6793144W1712783605What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.