ArticleThe Journal of cell biology1998
Calcium determines the supramolecular organization of fibrillin-rich microfibrils.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 64 citations in OpenAlex.
- Review
- Fibulin-4 exerts a dual role in LTBP-4L-mediated matrix assembly and function.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Fell-Muir Lecture: Fibrillin microfibrils: structural tensometers of elastic tissues?International journal of experimental pathology · 2017Review
- A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues.Redox biology · 2015Article
- Localized micro- and nano-scale remodelling in the diabetic aorta.Acta biomaterialia · 2014Article
- Article
- Tissue elasticity and the ageing elastic fibre.Age (Dordrecht, Netherlands) · 2009Review
- The molecular genetics of Marfan syndrome and related disorders.Journal of medical genetics · 2006Review
- Substrate-dependent morphology of supramolecular assemblies: fibrillin and type-VI collagen microfibrils.Biophysical journal · 2004Article
- Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization.Structure (London, England : 1993) · 2004Article
- Fibrillin: from microfibril assembly to biomechanical function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2002Review
- Fibrillin-rich microfibrils: elastic biopolymers of the extracellular matrix.Journal of muscle research and cell motility · 2002Review
- The supramolecular organization of fibrillin-rich microfibrils.The Journal of cell biology · 2001Article
- Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling.The Biochemical journal · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microfibrils are ubiquitous fibrillin-rich polymers that are thought to provide long-range elasticity to extracellular matrices, including the zonular filaments of mammalian eyes. X-ray diffraction of hydrated bovine zonular filaments demonstrated meridional diffraction peaks indexing on a fundamental axial periodicity (D) of approximately 56 nm. A Ca2+-induced reversible change in the intensities of the meridional Bragg peaks indicated that supramolecular rearrangements occurred in response to altered concentrations of free Ca2+. In the presence of Ca2+, the dominant diffracting subspecies were microfibrils aligned in an axial 0.33-D stagger. The removal of Ca2+ caused an enhanced regularity in molecular spacing of individual microfibrils, and the contribution from microfibrils not involved in staggered arrays became more dominant. Scanning transmission electron microscopy of isolated microfibrils revealed that Ca2+ removal or addition caused significant, reversible changes in microfibril mass distribution and periodicity. These results were consistent with evidence from x-ray diffraction. Simulated meridional x-ray diffraction profiles and analyses of isolated Ca2+-containing, staggered microfibrillar arrays were used to interpret the effects of Ca2+. These observations highlight the importance of Ca2+ to microfibrils and microfibrillar arrays in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.