ArticleMolecular and cellular biology1998
Fission yeast rad12+ regulates cell cycle checkpoint control and is homologous to the Bloom's syndrome disease gene.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 89 citations in OpenAlex.
- Review
- Checkpoint functions of RecQ helicases at perturbed DNA replication fork.Current genetics · 2021Review
- RecQ DNA Helicase Rqh1 Promotes Rad3Molecular and cellular biology · 2020Article
- Review
- DNA topoisomerase III localizes to centromeres and affects centromeric CENP-A levels in fission yeast.PLoS genetics · 2013Article
- Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition.The Journal of biological chemistry · 2010Article
- Binding and activation of DNA topoisomerase III by the Rmi1 subunit.The Journal of biological chemistry · 2007Article
- Mus81-Eme1-dependent and -independent crossovers form in mitotic cells during double-strand break repair in Schizosaccharomyces pombe.Molecular and cellular biology · 2007Article
- Cytoplasmatic post-transcriptional regulation and intracellular signalling.Molecular genetics and genomics : MGG · 2007Review
- Rqh1 blocks recombination between sister chromatids during double strand break repair, independent of its helicase activity.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest.Molecular and cellular biology · 2006Article
- RecQ helicases: lessons from model organisms.Nucleic acids research · 2006Review
- RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex.The EMBO journal · 2005Article
- Article
- Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex.Molecular and cellular biology · 2005Article
- The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.Molecular genetics and genomics : MGG · 2005Article
- RecQ helicases: suppressors of tumorigenesis and premature aging.The Biochemical journal · 2003Review
- RecQ family helicases: roles as tumor suppressor proteins.Oncogene · 2002Review
- The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes.Nucleic acids research · 2002Article
- mcl1+, the Schizosaccharomyces pombe homologue of CTF4, is important for chromosome replication, cohesion, and segregation.Eukaryotic cell · 2002Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
The human BLM gene is a member of the Escherichia coli recQ helicase family, which includes the Saccharomyces cerevisiae SGS1 and human WRN genes. Defects in BLM are responsible for the human disease Bloom's syndrome, which is characterized in part by genomic instability and a high incidence of cancer. Here we describe the cloning of rad12+, which is the fission yeast homolog of BLM and is identical to the recently reported rhq1+ gene. We showed that rad12 null cells are sensitive to DNA damage induced by UV light and gamma radiation, as well as to the DNA synthesis inhibitor hydroxyurea. Overexpression of the wild-type rad12+ gene also leads to sensitivity to these agents and to defects associated with the loss of the S-phase and G2-phase checkpoint control. We showed genetically and biochemically that rad12+ acts upstream from rad9+, one of the fission yeast G2 checkpoint control genes, in regulating exit from the S-phase checkpoint. The physical chromosome segregation defects seen in rad12 null cells combined with the checkpoint regulation defect seen in the rad12+ overproducer implicate rad12+ as a key coupler of chromosomal integrity with cell cycle progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.