ArticleMolecular and cellular biology1998
The Drosophila polycomb group protein Psc contacts ph and Pc through specific conserved domains.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 85 citations in OpenAlex.
- More than SAM: mechanisms of action of the Polycomb group protein polyhomeotic.Nucleus (Austin, Tex.) · 2026Review
- Comprehensive Biophysical Profiling Evidences Self-Oligomerization of Bacterially Expressed Pc Protein.Chembiochem : a European journal of chemical biology · 2026Article
- Structure and Function of the Polycomb Repressive Complexes PRC1 and PRC2.International journal of molecular sciences · 2022Article
- EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of Neuronal Differentiation.Frontiers in neuroscience · 2022Article
- An Unexpected Regulatory Cascade Governs a Core Function of the Drosophila PRC1 Chromatin Protein Su(z)2.Genetics · 2017Article
- Adaptive selection and coevolution at the proteins of the Polycomb repressive complexes in Drosophila.Heredity · 2016Article
- Chromatin topology is coupled to Polycomb group protein subnuclear organization.Nature communications · 2016Article
- Drosophila Cyclin G and epigenetic maintenance of gene expression during development.Epigenetics & chromatin · 2015Article
- Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs.Structure (London, England : 1993) · 2013Article
- Article
- Polycomb group genes Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.PloS one · 2012Article
- Molecular genetic analysis of Suppressor 2 of zeste identifies key functional domains.Genetics · 2009Article
- RAWUL: a new ubiquitin-like domain in PRC1 ring finger proteins that unveils putative plant and worm PRC1 orthologs.BMC genomics · 2008Article
- Cloning and characterization of mr-s, a novel SAM domain protein, predominantly expressed in retinal photoreceptor cells.BMC developmental biology · 2006Article
- Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function.Molecular and cellular biology · 2005Article
- Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity.Molecular and cellular biology · 2004Article
- Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma-derived cell lines.The American journal of pathology · 2004Article
- The Drosophila Corto protein interacts with Polycomb-group proteins and the GAGA factor.Nucleic acids research · 2003Article
- batman Interacts with polycomb and trithorax group genes and encodes a BTB/POZ protein that is included in a complex containing GAGA factor.Molecular and cellular biology · 2003Article
- Pleiohomeotic can link polycomb to DNA and mediate transcriptional repression.Molecular and cellular biology · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Polycomb group proteins are transcriptional repressors that are thought to act through multimeric nuclear complexes. We show that ph and Psc coprecipitate with Pc from nuclear extracts. We have analyzed the domains required for the association of Psc with ph and Pc by using the yeast two-hybrid system and an in vitro protein-binding assay. Psc and ph interact through regions of sequence conservation with mammalian homologs, i.e., the H1 domain of ph (amino acids 1297 to 1418) and the helix-turn-helix-containing region of Psc (amino acids 336 to 473). Psc contacts Pc primarily at the helix-turn-helix-containing region of Psc (amino acids 336 to 473), but also at the ring finger (amino acids 250 to 335). The Pc chromobox is not required for this interaction. We discuss the implication of these results for the nature of the complexes formed by Polycomb group proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.