ArticleClinical and experimental immunology1998
Anti-ribosomal antibodies bind the Sm proteins D and B/B'.
Article in Clinical and experimental immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Review
- Neuropsychiatric Systemic Lupus Erythematosus: Molecules Involved in Its Imunopathogenesis, Clinical Features, and Treatment.Molecules (Basel, Switzerland) · 2024Review
- Lupus anti-ribosomal P autoantibody proteomes express convergent biclonal signatures.Clinical and experimental immunology · 2016Article
- Antibodies directed against ribosomal P proteins cross-react with phospholipids.Clinical and experimental immunology · 2007Article
- Are anti-ribosomal P protein antibodies relevant in systemic lupus erythematosus?Clinical reviews in allergy & immunology · 2007Review
- Characterization of the human autoimmune response to the major C-terminal epitope of the ribosomal P proteins.Journal of molecular medicine (Berlin, Germany) · 2003Article
- Anti-ribosomal antibodies from lupus patients bind DNA.Clinical and experimental immunology · 2002Article
- Fine specificity of autoantibodies to calreticulin: epitope mapping and characterization.Clinical and experimental immunology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to analyse the specificity of human anti-ribosomal P protein antibodies, anti-ribosomal P protein antibodies were affinity-purified from the sera of lupus patients. Their binding capacity towards recombinant SmD protein and recombinant SmB/B' protein was evaluated by immunoblot and ELISA. Epitope mapping of SmD was performed by means of synthetic peptides. Anti-ribosomal P protein antibodies bound recombinant SmD (5/10) and SmB/B' (4/10) on immunoblot; 6/10 showed binding capacity to SmD on ELISA. Inhibition experiments using ELISA confirmed the specificity of this binding. Our data indicate the cross-reactivity of spontaneously developed anti-ribosomal P protein antibodies with the B/B' and D constituents of the Sm complex. The coexistence of anti-Sm and anti-ribosomal antibodies in lupus sera may therefore be due, at least in part, to the reactivity of a single autoantibody population.
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