ArticleClinical and experimental immunology1998
Suppression of IL-6 biological activities by activin A and implications for inflammatory arthropathies.
Article in Clinical and experimental immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 97 citations in OpenAlex.
- Short-term overloading exercise attenuates articular chondrocyte features partly via synovium-cartilage interactions mediated by inhibin subunit beta A.Scientific reports · 2025Article
- TGFβ and activin A in the tumor microenvironment in colorectal cancer.Gene reports · 2019Article
- The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts.Arthritis research & therapy · 2019Article
- Immunoselected STRO-3Stem cell research & therapy · 2017Article
- Immunoregulation by members of the TGFβ superfamily.Nature reviews. Immunology · 2016Review
- Activin A Predicts Left Ventricular Remodeling and Mortality in Patients with ST-Elevation Myocardial Infarction.Acta Cardiologica Sinica · 2016Article
- Uric acid: a modulator of prostate cells and activin sensitivity.Molecular and cellular biochemistry · 2016Article
- The immunoregulatory and fibrotic roles of activin A in allergic asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Review
- Activin A: a potential therapeutic target for characterizing and stopping joint pain early in rheumatoid arthritis patients.Inflammation · 2014Article
- Activin, neutrophils, and inflammation: just coincidence?Seminars in immunopathology · 2013Review
- 15-deoxy-Δ12,14 -prostaglandin J 2 Down-Regulates Activin-Induced Activin Receptor, Smad, and Cytokines Expression via Suppression of NF- κ B and MAPK Signaling in HepG2 Cells.PPAR research · 2013Article
- Activin A expression regulates multipotency of mesenchymal progenitor cells.Stem cell research & therapy · 2010Article
- Upregulation of activin signaling in experimental colitis.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease.The Journal of experimental medicine · 2009Article
- Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells.Rheumatology international · 2007Article
- Activin induces tactile allodynia and increases calcitonin gene-related peptide after peripheral inflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Activin a in the regulation of corneal neovascularization and vascular endothelial growth factor expression.The American journal of pathology · 2004Article
- Functional analysis of an arthritogenic synovial fibroblast.Arthritis research & therapy · 2003Article
- Reversible increase of serum activin A levels in women with Graves' disease.Journal of endocrinological investigation · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Activin A is a cytokine whose multiple functions have yet to be fully determined. In this study, the role of proinflammatory cytokines in regulatory control of activin A production was shown in synoviocytes and chondrocytes. Additional facets of functional inflammation-related activities of activin A were also determined. Results showed that activin A concentrations in the synovial fluid of patients with rheumatoid arthritis and gout were elevated relative to those in patients with osteoarthritis. Further studies showed that production of activin A by synoviocytes and chondrocytes in culture was stimulated by cytokines such as IL-1, transforming growth factor-beta (TGF-beta), interferon-gamma (IFN-gamma), and IL-8, consistent with previous studies in regard to the control of activin A production in marrow stromal cells and monocytes by cytokines, glucocorticoids and retinoic acid. In addition, the relationship of activin A to IL-6-induced biological activities was investigated. Three major IL-6 activities involved in inflammatory responses were found to be suppressed by activin A. In a dose-dependent manner, activin A efficiently suppressed IL-6-induced proliferation of 7TD1 B lymphoid cells, phagocytic activity of monocytic M1 cells, and fibrinogen production in HepG2. Therefore, it is likely that activin A serves as a suppressor for IL-6, dampening inflammatory responses, and has the potential to perform some previously unrecognized roles in inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.