ArticleClinical and experimental immunology1998
Epitopes expressed in myasthenia gravis (MG) thymomas are not recognized by patients' T cells or autoantibodies.
Article in Clinical and experimental immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 26 citations in OpenAlex.
- Behçet's disease: infectious aetiology, new autoantigens, and HLA-B51.Annals of the rheumatic diseases · 2001Review
- Detection of antibodies directed against the cytoplasmic region of the human acetylcholine receptor in sera from myasthenia gravis patients.Clinical and experimental immunology · 1999Article
- Antibodies to ion channels in paraneoplastic disorders.Brain pathology (Zurich, Switzerland) · 1999Review
- A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes.The Journal of clinical investigation · 1998Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most thymic epithelial tumours that associate with MG express an epitope that resembles the sequence alpha373-380 from the cytoplasmic loop of the acetylcholine receptor (AChR). It has been proposed that sensitization to this linear epitope initiates autoimmunity to the AChR in thymoma-associated MG. We therefore tested whether MG/thymoma patients have T cell responses or antibodies to this region of the AChR. We found no significant recognition of the alpha309-417 region by their thymoma or peripheral blood T cells, or by their serum anti-AChR antibodies. Instead, the T cell epitopes that were recognized, like the previously characterized B cell epitopes, were in the extracellular AChR domain.
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