ArticleIntensive care medicine1998
Cerebral perfusion pressure and intracranial pressure in relation to neuropsychological outcome.
Article in Intensive care medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 26 citations in OpenAlex.
- Low brain oxygenation and differences in neuropsychological outcomes following severe pediatric TBI.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Article
- Timing of intracranial hypertension following severe traumatic brain injury.Neurocritical care · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe study attempted to examine the relationship between neuropsychological functioning and reduced cerebral perfusion pressure (CPP), raised intracranial pressure (ICP), and reduced mean arterial pressure (MAP), monitored during intensive care treatment.
designThis prospective follow-up study included consecutive patients and evaluated outcome at 6 months postinjury by the administration of a neuropsychological test battery.
settingThe study was conducted at the University Hospital of Gent, Belgium. PATIENTS AND
participantsOver a 30-month period, 43 patients were included. Inclusion criteria were the following: hospital admission following closed head injury. ICP monitoring, no medical history of central nervous system disease or mental retardation, survival for at least 6 months, and informed consent for participation.
interventionsAll patients received the hospital's standard treatment for head injury, which remained unchanged during the study period. MEASUREMENTS AND
resultsReduced CPP was analyzed using the number of observed values below 70 mmhg, raised ICP using the number of values above 20 mmHg, and MAP using the number of values below 80 mmHg. The neuropsychological test battery included 11 measures of attention, information processing, motor reaction time, memory, learning, visuoconstruction, verbal fluency, and mental flexibility. No linear relationships were found between overall neuropsychological impairment and episodes of reduced CPP, raised ICP, or reduced MAP.
conclusionsAlthough reduced CPP and raised ICP are frequent, often fatal, complications of head injury, in survivors they do not seem to be related to later neuropsychological functioning.
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Registered trials
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