ArticleThe Journal of experimental medicine1998
One of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 69 citations in OpenAlex.
- Modifications to rhesus macaque TCR constant regions improve TCR cell surface expression.PloS one · 2025Article
- Siglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia.Nature communications · 2024Article
- A CD3 humanized mouse model unmasked unique features of T-cell responses to bispecific antibody treatment.Blood advances · 2024Article
- Partitioning stable and unstable expression level variation in cell populations: A theoretical framework and its application to the T cell receptor.PLoS computational biology · 2020Article
- Structural understanding of T cell receptor triggering.Cellular & molecular immunology · 2020Review
- Structural Model of the Extracellular Assembly of the TCR-CD3 Complex.Cell reports · 2016Article
- αβ TCR-mediated recognition: relevance to tumor-antigen discovery and cancer immunotherapy.Cancer immunology research · 2015Review
- Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination.Frontiers in immunology · 2015Review
- An immunology primer for computational modelers.Journal of pharmacokinetics and pharmacodynamics · 2014Review
- Structure of the chicken CD3εδ/γ heterodimer and its assembly with the αβT cell receptor.The Journal of biological chemistry · 2014Article
- The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function.Immunological reviews · 2012Review
- Effects of autoclaving and high pressure on allergenicity of hazelnut proteins.Journal of clinical bioinformatics · 2012Article
- TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling.Frontiers in immunology · 2012Article
- TCR Signaling Emerges from the Sum of Many Parts.Frontiers in immunology · 2012Article
- Mechanisms for T cell receptor triggering.Nature reviews. Immunology · 2011Review
- Extensive analysis of D-J-C arrangements allows the identification of different mechanisms enhancing the diversity in sheep T cell receptor beta-chain repertoire.BMC genomics · 2010Article
- The alphabeta T cell receptor is an anisotropic mechanosensor.The Journal of biological chemistry · 2009Article
- A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor.The Journal of biological chemistry · 2006Article
- Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A recent crystal structure of the N15 alpha/beta-T cell receptor (TCR) in complex with an Fab derived from the H57 Cbeta-specific monoclonal antibody (mAb) shows the mAb fragment interacting with the elongated FG loop of the Cbeta domain. This loop creates one side wall of a cavity within the TCR Ti-alpha/beta constant region module (CalphaCbeta) while the CD and EF loops of the Calpha domain form another wall. The cavity size is sufficient to accommodate a single nonglycosylated Ig domain such as the CD3epsilon ectodomain. By using specific mAbs to mouse TCR-beta (H57) and CD3epsilon (2C11) subunits, we herein provide evidence that only one of the two CD3epsilon chains within the TCR complex is located in close proximity to the TCR Cbeta FG loop, in support of the above notion. Moreover, analysis of T cells isolated from transgenic mice expressing both human and mouse CD3epsilon genes shows that the heterologous human CD3epsilon component can replace the mouse CD3epsilon at this site. The location of one CD3epsilon subunit within the rigid constant domain module has implications for the mechanism of signal transduction throughout T cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.