ArticleThe EMBO journal1998
The Ssn6-Tup1 repressor complex of Saccharomyces cerevisiae is involved in the osmotic induction of HOG-dependent and -independent genes.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 70 citations in OpenAlex.
- Article
- Osmolyte accumulation regulates the SUMOylation and inclusion dynamics of the prionogenic Cyc8-Tup1 transcription corepressor.PLoS genetics · 2019Article
- Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells.Microbial cell (Graz, Austria) · 2014Article
- Crystal structure of the N-terminal domain of the yeast general corepressor Tup1p and its functional implications.The Journal of biological chemistry · 2012Article
- Two cation transporters Ena1 and Nha1 cooperatively modulate ion homeostasis, antifungal drug resistance, and virulence of Cryptococcus neoformans via the HOG pathway.Fungal genetics and biology : FG & B · 2012Article
- Identification and characterization of genes required for cell-to-cell fusion in Neurospora crassa.Eukaryotic cell · 2011Article
- Deletion of a subgroup of ribosome-related genes minimizes hypoxia-induced changes and confers hypoxia tolerance.Physiological genomics · 2011Article
- Late phase of the endoplasmic reticulum stress response pathway is regulated by Hog1 MAP kinase.The Journal of biological chemistry · 2010Article
- Adaptive evolution of baker's yeast in a dough-like environment enhances freeze and salinity tolerance.Microbial biotechnology · 2010Article
- The Cek1 and Hog1 mitogen-activated protein kinases play complementary roles in cell wall biogenesis and chlamydospore formation in the fungal pathogen Candida albicans.Eukaryotic cell · 2006Article
- Validation of a flour-free model dough system for throughput studies of baker's yeast.Applied and environmental microbiology · 2005Article
- Environmental suppression of Neurospora crassa cot-1 hyperbranching: a link between COT1 kinase and stress sensing.Eukaryotic cell · 2003Article
- Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae.Current genetics · 2003Review
- Role of fission yeast Tup1-like repressors and Prr1 transcription factor in response to salt stress.Molecular biology of the cell · 2002Article
- Functional dissection of the global repressor Tup1 in yeast: dominant role of the C-terminal repression domain.Genetics · 2002Article
- Osmotic stress signaling and osmoadaptation in yeasts.Microbiology and molecular biology reviews : MMBR · 2002Review
- Article
- Article
- Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress.The EMBO journal · 2001Article
- The Sko1p repressor and Gcn4p activator antagonistically modulate stress-regulated transcription in Saccharomyces cerevisiae.Molecular and cellular biology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The response of yeast to osmotic stress has been proposed to rely on the HOG-MAP kinase signalling pathway and on transcriptional activation mediated by STRE promoter elements. However, the osmotic induction of HAL1, an important determinant of salt tolerance, is HOG independent and occurs through the release of transcriptional repression. We have identified an upstream repressing sequence in HAL1 promoter (URSHAL1) located between -231 and -156. This promoter region was able to repress transcription from a heterologous promoter and to bind proteins in non-stressed cells, but not in salt-treated cells. The repression conferred by URSHAL1 is mediated through the Ssn6-Tup1 protein complex and is abolished in the presence of osmotic stress. The Ssn6-Tup1 co-repressor is also involved in the regulation of HOG-dependent genes such as GPD1, CTT1, ALD2, ENA1 and SIP18, and its deletion can suppress the osmotic sensitivity of hog1 mutants. We propose that the Ssn6-Tup1 repressor complex might be a general component in the regulation of osmostress responses at the transcriptional level of both HOG-dependent and -independent genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.