ArticleThe EMBO journal1998
Early evolutionary origin of the neurotrophin receptor family.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Neurotrophins and their receptors in the peripheral nervous system and non-nervous tissue of fish.Fish physiology and biochemistry · 2025Review
- A, B, C's of Trk Receptors and Their Ligands in Ocular Repair.International journal of molecular sciences · 2022Review
- Zebrafish an experimental model of Huntington's disease: molecular aspects, therapeutic targets and current challenges.Molecular biology reports · 2021Review
- BDNF, Brain, and Regeneration: Insights from Zebrafish.International journal of molecular sciences · 2018Review
- Neurotrophin, p75, and Trk Signaling Module in the Developing Nervous System of the Marine Annelid Platynereis dumerilii.BioMed research international · 2016Article
- A novel fibroblast growth factor receptor family member promotes neuronal outgrowth and synaptic plasticity in aplysia.Amino acids · 2014Article
- A single Aplysia neurotrophin mediates synaptic facilitation via differentially processed isoforms.Cell reports · 2013Article
- Expression of TrkC receptors in the developing brain of the Monodelphis opossum and its effect on the development of cortical cells.PloS one · 2013Article
- Molluscan neurons in culture: shedding light on synapse formation and plasticity.Journal of molecular histology · 2012Review
- The genome sequence of the protostome Daphnia pulex encodes respective orthologues of a neurotrophin, a Trk and a p75NTR: evolution of neurotrophin signaling components and related proteins in the bilateria.BMC evolutionary biology · 2009Article
- Article
- Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation.Genes & development · 2007Article
- Endocrine disruption in aquatic pulmonate molluscs: few evidences, many challenges.Ecotoxicology (London, England) · 2007Review
- A genomic view of the sea urchin nervous system.Developmental biology · 2006Article
- Neurotrophins and the immune system.Journal of anatomy · 2003Review
- The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons.The EMBO journal · 2002Article
- Immunohistochemical localization of BDNF-, TrkB- and TrkA-like proteins in the teleost lateral line system.Journal of anatomy · 2002Article
- Neurotrophic actions of a novel molluscan epidermal growth factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Excitatory synaptogenesis between identified Lymnaea neurons requires extrinsic trophic factors and is mediated by receptor tyrosine kinases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Nerve growth factor acutely reduces chemical transmission by means of postsynaptic TrkA-like receptors in squid giant synapse.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotrophins and their Trk receptors play a crucial role in the development and maintenance of the vertebrate nervous system, but to date no component of this signalling system has been found in invertebrates. We describe a molluscan Trk receptor, designated Ltrk, from the snail Lymnaea stagnalis. The full-length sequence of Ltrk reveals most of the characteristics typical of Trk receptors, including highly conserved transmembrane and intracellular tyrosine kinase domains, and a typical extracellular domain of leucine-rich motifs flanked by cysteine clusters. In addition, Ltrk has a unique N-terminal extension and lacks immunoglobulin-like domains. Ltrk is expressed during development in a stage-specific manner, and also in the adult, where its expression is confined to the central nervous system and its associated endocrine tissues. Ltrk has the highest sequence identity with the TrkC mammalian receptor and, when exogenously expressed in fibroblasts or COS cells, binds human NT-3, but not NGF or BDNF, with an affinity of 2.5 nM. These findings support an early evolutionary origin of the Trk family as neuronal receptor tyrosine kinases and suggest that Trk signalling mechanisms may be highly conserved between vertebrates and invertebrates.
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