ArticleMolecular and cellular biochemistry1998
Receptor-Ck-dependent regulation of genes involved in the cell cycle.
Article in Molecular and cellular biochemistry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Lipid profile in oral submucous fibrosis.Lipids in health and disease · 2009Article
- Receptor Ck-dependent signaling regulates hTERT gene transcription.BMC cell biology · 2006Article
- Role of cholesterol in parasitic infections.Lipids in health and disease · 2005Review
- Receptor-Ck regulates giardia encystation process.Molecular and cellular biochemistry · 2001Article
- Molecular link between cholesterol, cytokines and atherosclerosis.Molecular and cellular biochemistry · 2001Review
- Receptor-Ck regulates membrane-bound 125 kDa protein having affinity for genomic sterol regulatory sequence.Molecular and cellular biochemistry · 2001Article
- Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27).Molecular and cellular biochemistry · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was addressed to understand the interrelationship between Receptor-Ck activation, mevalonate pathway and primary response genes such as c-fos, c-myc and cyclin 'D' involved in the cell cycle. The results reported here unambiguously revealed that the phosphatidic acid (generated through the activation of Receptor-Ck by cholesterol) regulates mevalonate pathway, DNA synthesis as well as expression of genes coding for c-fos, c-myc and cyclin 'D'. By using the specific blockers of ras farnesylation as well as phospholipase D, it became apparent that phosphatidic acid regulates two processes: (a) activation of Gap-ras pathway leading to the expression of c-fos, c-myc proto-oncogenes probably through the activation of NF1 transcription factor; (b) cleavage of 125 kDa endoplasmic reticulum protein leading to the generation of 47 kDa protein factor which not only regulates mevalonate pathway but also has an ability to heterodimerize with Receptor-Ck protein and this heterodimer may be responsible for the regulation of cyclin 'D' expression probably by binding to the SRE like sequence present in the promoter region of this gene. On the basis of these findings, we propose a pathway through which Receptor-Ck upon endocytosis regulate these primary response genes (c-fos, c-myc, cyclin 'D') involved in the cell cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.