ArticleGenetics1998
Signatures of population expansion in microsatellite repeat data.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
68 citing papers in PubMed, 238 citations in OpenAlex.
- Article
- Reduced genetic diversity associated with the northern expansion of an amphibian species with high habitat specialization,Ecology and evolution · 2022Article
- Microsatellite analysis reveals connectivity among geographically distant transmission zones of Plasmodium vivax in the Peruvian Amazon: A critical barrier to regional malaria elimination.PLoS neglected tropical diseases · 2019Article
- Genetic signatures of small effective population sizes and demographic declines in an endangered rattlesnake,Evolutionary applications · 2019Article
- Genetic demography at the leading edge of the distribution of a rabies virus vector.Ecology and evolution · 2017Article
- A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets.PLoS genetics · 2017Article
- Article
- A linkage disequilibrium perspective on the genetic mosaic of speciation in two hybridizing Mediterranean white oaks.Heredity · 2015Article
- An analytical framework in the general coalescent tree setting for analyzing polymorphisms created by two mutations.Journal of mathematical biology · 2015Article
- Genetic characterization and structure of the endemic Colombian silvery brown bare-face tamarin, Saguinus leucopus (Callitrichinae, Cebidae, Primates).Primates; journal of primatology · 2014Article
- Detecting past changes of effective population size.Evolutionary applications · 2014Article
- Population genetic and admixture analyses of Culex pipiens complex (Diptera: Culicidae) populations in California, United States.The American journal of tropical medicine and hygiene · 2013Article
- Factors influencing ascertainment bias of microsatellite allele sizes: impact on estimates of mutation rates.Genetics · 2013Article
- Random fluctuation of selection coefficients and the extent of nucleotide variation in human populations.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Population genetic structure of sexual and parthenogenetic damselflies inferred from mitochondrial and nuclear markers.Heredity · 2012Article
- Joint inference of microsatellite mutation models, population history and genealogies using transdimensional Markov Chain Monte Carlo.Genetics · 2011Article
- A genomic portrait of human microsatellite variation.Molecular biology and evolution · 2011Article
- The number of alleles at a microsatellite defines the allele frequency spectrum and facilitates fast accurate estimation of theta.Molecular biology and evolution · 2010Article
- Uncoordinated phylogeography of Borrelia burgdorferi and its tick vector, Ixodes scapularis.Evolution; international journal of organic evolution · 2010Article
- Genetic structure of Anopheles (Nyssorhynchus) marajoara (Diptera: Culicidae) in Colombia.The American journal of tropical medicine and hygiene · 2010Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
To examine the signature of population expansion on genetic variability at microsatellite loci, we consider a population that evolves according to the time-continuous Moran model, with growing population size and mutations that follow a general asymmetric stepwise mutation model. We present calculations of expected allele-size variance and homozygosity at a locus in such a model for several variants of growth, including stepwise, exponential, and logistic growth. These calculations in particular prove that population bottleneck followed by growth in size causes an imbalance between allele size variance and heterozygosity, characterized by the variance being transiently higher than expected under equilibrium conditions. This effect is, in a sense, analogous to that demonstrated before for the infinite allele model, where the number of alleles transiently increases after a stepwise growth of population. We analyze a set of data on tetranucleotide repeats that reveals the imbalance expected under the assumption of bottleneck followed by population growth in two out of three major racial groups. The imbalance is strongest in Asians, intermediate in Europeans, and absent in Africans. This finding is consistent with previous findings by others concerning the population expansion of modern humans, with the bottleneck event being most ancient in Africans, most recent in Asians, and intermediate in Europeans. Nevertheless, the imbalance index alone cannot reliably estimate the time of initiation of population expansion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.