ArticleGenetics1998
Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Identifying Key Genetic Regions for Cell Sheet Morphogenesis on Chromosome 2L Using aG3 (Bethesda, Md.) · 2020Article
- Identifying Genetic Players in Cell Sheet Morphogenesis Using aG3 (Bethesda, Md.) · 2018Article
- The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila.PloS one · 2016Article
- Invadolysin acts genetically via the SAGA complex to modulate chromosome structure.Nucleic acids research · 2015Article
- A lack of association between theExperimental and therapeutic medicine · 2015Article
- Actomyosin-dependent cortical dynamics contributes to the prophase force-balance in the early Drosophila embryo.PloS one · 2011Article
- Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis.Developmental biology · 2010Article
- A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila.PloS one · 2009Article
- Actomyosin purse strings: renewable resources that make morphogenesis robust and resilient.HFSP journal · 2008Article
- The nonmuscle myosin phosphatase PP1beta (flapwing) negatively regulates Jun N-terminal kinase in wing imaginal discs of Drosophila.Genetics · 2007Article
- Sometimes the result is not the answer: the truths and the lies that come from using the complementation test.Genetics · 2006Review
- The essential role of PP1beta in Drosophila is to regulate nonmuscle myosin.Molecular biology of the cell · 2004Article
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- Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis.Genetics · 2003Article
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- An enhancer trap screen for ecdysone-inducible genes required for Drosophila adult leg morphogenesis.Genetics · 2000Article
- Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis.Genetics · 2000Article
- Distinct tissue distributions and subcellular localizations of differently phosphorylated forms of the myosin regulatory light chain in Drosophila.Gene expression patterns : GEPArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Drosophila is an ideal metazoan model system for analyzing the role of nonmuscle myosin-II (henceforth, myosin) during development. In Drosophila, myosin function is required for cytokinesis and morphogenesis driven by cell migration and/or cell shape changes during oogenesis, embryogenesis, larval development and pupal metamorphosis. The mechanisms that regulate myosin function and the supramolecular structures into which myosin incorporates have not been systematically characterized. The genetic screens described here identify genomic regions that uncover loci that facilitate myosin function. The nonmuscle myosin heavy chain is encoded by a single locus, zipper. Contiguous chromosomal deficiencies that represent approximately 70% of the euchromatic genome were screened for genetic interactions with two recessive lethal alleles of zipper in a second-site noncomplementation assay for the malformed phenotype. Malformation in the adult leg reflects aberrations in cell shape changes driven by myosin-based contraction during leg morphogenesis. Of the 158 deficiencies tested, 47 behaved as second-site noncomplementors of zipper. Two of the deficiencies are strong interactors, 17 are intermediate and 28 are weak. Finer genetic mapping reveals that mutations in cytoplasmic tropomyosin and viking (collagen IV) behave as second-site noncomplementors of zipper during leg morphogenesis and that zipper function requires a previously uncharacterized locus, E3.10/J3.8, for leg morphogenesis and viability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.