ArticleGenetics1998
Differential response of mouse male germ-cell stages to radiation-induced specific-locus and dominant mutations.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Characteristics of induced mutations in offspring derived from irradiated mouse spermatogonia and mature oocytes.Scientific reports · 2020Article
- Dynamic Variations in Genetic Integrity Accompany Changes in Cell Fate.Stem cells and development · 2016Article
- Enhanced genetic integrity in mouse germ cells.Biology of reproduction · 2013Article
- Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice.Molecular reproduction and development · 2011Article
- Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- BAX and tumor suppressor TRP53 are important in regulating mutagenesis in spermatogenic cells in mice.Biology of reproduction · 2010Article
- Stillbirth and neonatal death in relation to radiation exposure before conception: a retrospective cohort study.Lancet (London, England) · 2010Article
- Recovery of a low mutant frequency after ionizing radiation-induced mutagenesis during spermatogenesis.Mutation research · 2008Article
- Assessing human germ-cell mutagenesis in the Postgenome Era: a celebration of the legacy of William Lawson (Bill) Russell.Environmental and molecular mutagenesis · 2007Article
- Review
- Untargeted mutation of the maternally derived mouse hypervariable minisatellite allele in F1 mice born to irradiated spermatozoa.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an attempt to provide a systematic assessment of the frequency and nature of mutations induced in successive stages of spermato- and spermiogenesis, X-irradiated male mice were re-mated at weekly intervals, and large samples of progeny, observed from birth onward, were scored and genetically tested for recessive mutations at seven specific loci and for externally recognizable dominant mutations. Productivity findings provided a rough measure of induced dominant-lethal frequencies. A qualitative assessment of specific-locus mutations (which include deletions and other rearrangements) was made on the basis of homozygosity test results, as well as from information derived from more recent complementation studies and molecular analyses. Both recessive and dominant visibles revealed clear distinctions between spermatogonia and postspermatogonial stages. In addition, differences for both of these endpoints, as well as for presumed dominant lethals, were found among various postspermatogonial stages. It may be concluded that radiation produces its maximum rates of genetic damage in germ-cell stages ranging from midpachytene spermatocytes through early spermatids, a pattern unlike any of those that have been defined for chemicals; further, the frequency peaks for radiation are lower and broader. The difference between post-stem-cell stages overall and stem-cell spermatogonia was smaller than is generally found with chemicals, not only with respect to the frequency but also the nature of mutations.
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Registered trials
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