ArticleProceedings of the National Academy of Sciences of the United States of America1998
Regulation of thalamic neurite outgrowth by the Eph ligand ephrin-A5: implications in the development of thalamocortical projections.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 147 citations in OpenAlex.
- Sensory modality-specific wiring of thalamocortical circuits.Nature reviews. Neuroscience · 2025Review
- Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Regulation of neuronal fate specification and connectivity of the thalamic reticular nucleus by the Ascl1-Isl1 transcriptional cascade.Cellular and molecular life sciences : CMLS · 2024Article
- Article
- Mechanistic insights into the pathogenesis of microtubule-targeting agent-induced peripheral neuropathy from pharmacogenetic and functional studies.Basic & clinical pharmacology & toxicology · 2022Review
- Intravital Imaging of Neocortical Heterotopia Reveals Aberrant Axonal Pathfinding and Myelination around Ectopic Neurons.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Modelling the emergence of whisker barrels.eLife · 2020Article
- Decreased maternal behavior and anxiety in ephrin-A5Genes, brain, and behavior · 2017Article
- Neurovascular patterning cues and implications for central and peripheral neurological disease.Surgical neurology international · 2017Review
- Parcellation of the thalamus into distinct nuclei reflects EphA expression and function.Gene expression patterns : GEP · 2013Article
- 'Til Eph do us part': intercellular signaling via Eph receptors and ephrin ligands guides cerebral cortical development from birth through maturation.Cerebral cortex (New York, N.Y. : 1991) · 2013Review
- Polysialylated NCAM and ephrinA/EphA regulate synaptic development of GABAergic interneurons in prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
- Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells.Nature communications · 2013Article
- Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain.The European journal of neuroscience · 2012Review
- Laminar expression of ephrin-A2 in primary somatosensory cortex of postnatal rats.Anatomical record (Hoboken, N.J. : 2007) · 2012Article
- What can we get from 'barrels': the rodent barrel cortex as a model for studying the establishment of neural circuits.The European journal of neuroscience · 2011Review
- Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex.PloS one · 2011Article
- mGluR5 in cortical excitatory neurons exerts both cell-autonomous and -nonautonomous influences on cortical somatosensory circuit formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- EphrinA5 protein distribution in the developing mouse brain.BMC neuroscience · 2010Article
- Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
The cerebral cortex is parcellated into different functional domains that receive distinct inputs from other cortical and subcortical regions. The molecular mechanisms underlying the specificity of connections of cortical afferents remain unclear. We report here that the Eph family tyrosine kinase receptor EphA5 and the ligand ephrin-A5 may play a key role in the exclusion of the limbic thalamic afferents from the sensorimotor cortex by mediating repulsive interactions. In situ hybridization shows that the EphA5 transcript is expressed at high levels in both cortical and subcortical limbic regions, including the frontal cortex, the subiculum, and the medial thalamic nuclei. In contrast, ephrin-A5 is transcribed abundantly in the sensorimotor cortex. Consistent with the complementary expression, the ligand inhibited dramatically the growth of neurites from neurons isolated from the medial thalamus but was permissive for the growth of neurites from lateral thalamic neurons, which is primarily nonlimbic. Similarly, the growth of neurites from Eph-A5-expressing neurons isolated from the subiculum was inhibited by ephrin-A5. Our studies suggest that the Eph family ligand ephrin-A5 serves as a general inhibitor of axonal growth from limbic neurons, which may serve to prevent innervation of inappropriate primary sensorimotor regions, thus contributing to the generation of specificity of thalamic cortical afferents.
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