ArticleProceedings of the National Academy of Sciences of the United States of America1998
Monosomy of a specific chromosome determines L-sorbose utilization: a novel regulatory mechanism in Candida albicans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
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Who cites it
107 citing papers in PubMed, 206 citations in OpenAlex.
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- Aneuploidy, polyploidy, and loss of heterozygosity distinguish serial bloodstream isolates ofbioRxiv : the preprint server for biology · 2025Article
- Strain background interacts with chromosome 7 aneuploidy to determine commensal and virulence phenotypes in Candida albicans.PLoS genetics · 2025Article
- Aneuploidy confers a unique transcriptional and phenotypic profile to Candida albicans.Nature communications · 2025Article
- Aneuploidy enables adaptation to brefeldin A inFrontiers in cellular and infection microbiology · 2025Article
- Single-cell detection of copy number changes reveals dynamic mechanisms of adaptation to antifungals in Candida albicans.Nature microbiology · 2024Article
- Strain background ofMicrobiology (Reading, England) · 2024Article
- Editorial: Mitochondrial function and dysfunction in pathogenic fungi.Frontiers in physiology · 2024Article
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- Aneuploidy and gene dosage regulate filamentation and host colonization byProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Aneuploidy enables cross-tolerance to unrelated antifungal drugs inFrontiers in microbiology · 2023Article
- Copy Number Variation and Allele Ratio Analysis in Candida albicans Using Whole Genome Sequencing Data.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Effects of aneuploidy on cell behaviour and function.Nature reviews. Molecular cell biology · 2022Review
- Chromatin profiling reveals heterogeneity in clinical isolates of the human pathogen Aspergillus fumigatus.PLoS genetics · 2022Article
- Aneuploidy Underlies Tolerance and Cross-Tolerance to Drugs in Candida parapsilosis.Microbiology spectrum · 2021Article
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- Systematic truncations of chromosome 4 and their responses to antifungals in Candida albicans.Journal, genetic engineering & biotechnology · 2021Article
47 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We report the identification of the gene, SOU1, required for L-sorbose assimilation in Candida albicans. The level of the expression of SOU1 is determined by the copy number of chromosome III (also denoted chromosome 5), such that monosomic strains assimilate L-sorbose, whereas disomic strains do not, in spite of the fact that SOU1 is not on this chromosome. We suggest that C. albicans contains a resource of potentially beneficial genes that are activated by changes in chromosome number, and that this elaborate mechanism regulates the utilization of food supplies and possibly other important functions, thus representing a novel general means for regulating gene expression in microbes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.