ArticleAntimicrobial agents and chemotherapy1998
Mutations in aarE, the ubiA homolog of Providencia stuartii, result in high-level aminoglycoside resistance and reduced expression of the chromosomal aminoglycoside 2'-N-acetyltransferase.
Article in Antimicrobial agents and chemotherapy, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 15 citations in OpenAlex.
- Quorum sensing regulates heteroresistance inFrontiers in microbiology · 2022Article
- Systematic Evaluation of Whole Genome Sequence-Based Predictions ofFrontiers in microbiology · 2020Article
- The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification.Nature microbiology · 2019Article
- Article
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4 authors at 2 institutions in 2 countries.
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Abstract
The aarE1 allele was identified on the basis of the resulting phenotype of increased aminoglycoside resistance. The aarE1 mutation also resulted in a small-colony phenotype and decreased levels of aac(2')-Ia mRNA. The deduced AarE gene product displayed 61% amino acid identity to the Escherichia coli UbiA protein, an octaprenyltransferase required for the second step of ubiquinone biosynthesis. Complementation experiments in both Providencia stuartii and E. coli demonstrated that aarE and ubiA are functionally equivalent.
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