Trial reportAntimicrobial agents and chemotherapy1998
Fluconazole pharmacokinetics in burn patients.
Trial report in Antimicrobial agents and chemotherapy, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Comparative Population Plasma and Tissue Pharmacokinetics of Micafungin in Critically Ill Patients with Severe Burn Injuries and Patients with Complicated Intra-Abdominal Infection.Antimicrobial agents and chemotherapy · 2016Trial
- Changes in fluconazole pharmacokinetics can impact on antifungal effectiveness in critically ill burn patients: a Pharmacokinetic-Pharmacodynamic (PK/PD) approach.Clinics (Sao Paulo, Brazil) · 2024Article
- Evaluation of Voriconazole and Posaconazole Dosing in Patients With Thermal Burn Injuries.Journal of burn care & research : official publication of the American Burn Association · 2022Article
- Developmental changes of fluconazole clearance in neonates and infants in relation to ontogeny of glomerular filtration rate: literature review and data analysis.Journal of pharmaceutical health care and sciences · 2018Article
- Comparison of the pharmacokinetics of linezolid in burn and non-burn rabbits.European journal of drug metabolism and pharmacokinetics · 2015Article
- [Not Available].Annals of burns and fire disasters · 2015Article
- Penetration of micafungin into the burn eschar in patients with severe burns.European journal of drug metabolism and pharmacokinetics · 2014Article
- Population pharmacokinetic analysis of fluconazole to predict therapeutic outcome in burn patients with Candida infection.Antimicrobial agents and chemotherapy · 2013Article
- Micafungin concentrations in the plasma and burn eschar of severely burned patients.Antimicrobial agents and chemotherapy · 2012Article
- Fluconazole plasma concentration measurement by liquid chromatography for drug monitoring of burn patients.Clinics (Sao Paulo, Brazil) · 2010Article
- Influence of burns on pharmacokinetics and pharmacodynamics of drugs used in the care of burn patients.Clinical pharmacokinetics · 2008Review
- Levofloxacin pharmacokinetics and pharmacodynamics in patients with severe burn injury.Antimicrobial agents and chemotherapy · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pharmacokinetics of fluconazole in nine adult patients with severe (30 to 95% total body surface area) burns were studied. There was no significant difference in half-life (t1/2), clearance (CL), or volume of distribution (V) over time in five patients on days 3 and 8 of the study (P > 0.05). Combined parameter estimates (means +/- standard deviations) for all nine patients for the two study periods were as follows: t1/2, 24.4 +/- 5.8 h; CL, 0.36 +/- 0.09 ml/min/kg; and V, 0.72 +/- 0.12 liters/kg. These estimates of t1/2 and CL in burn patients were approximately 13% shorter and 30% more rapid, respectively, than the most extreme estimates reported for other populations.
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