Evidence map›Paper›PMID 9557734›Full record

ArticleJournal of virology1998

Biological characterization of Rev variation in equine infectious anemia virus.

M Belshan, M E Harris, A E Shoemaker, T J Hope, S Carpenter

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

M BelshanDepartment of Microbiology, Immunology, and Preventive Medicine, Iowa State University, Ames 50011, USA.
M E Harris
A E Shoemaker
T J Hope
S Carpenter
Iowa State University · USSalk Institute for Biological Studies · US

Funding

COMMON FEATURES OF REV LIKE VIRAL REGULATORY PROTIENSR01AI035477 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HOPE, THOMAS J · 1994 to 2001
$533k
CLINICAL TRIALS FOR ANTIVIRAL THERAPIES-266030025-266030025N01AI030025 · NIAID · UNIVERSITY OF ALABAMA BIRMINGH · PI WHITLEY, RICHARD R · 2003 to 2006
–
NIAID NIH HHS AI35477NIAID NIH HHS N01 AI030025
6 · The paper itself

Abstract

Sequence analysis identified significant variation in the second exon of equine infectious anemia virus (EIAV) rev. Functional analysis indicated that limited amino acid variation in Rev significantly altered the export activity of the protein but did not affect Rev-dependent alternative splicing. EIAV Rev can mediate export through two independent cis-acting Rev-responsive elements (RREs), and differences among Rev variants were more pronounced when both RREs were present. Variation in Rev may be an important mechanism for regulation of virus replication in vivo and may contribute to changes in clinical disease.

Indexed as

Genetic VariationAlternative SplicingAmino Acid SequenceAnimalsEquidaeGene Products, revInfectious Anemia Virus, EquineMolecular Sequence DataRNA, ViralGene Products, revRNA, Viral

Identifiers

PMID9557734
PMCPMC109674
OpenAlexW2125716247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.