ArticleJournal of virology1998
Characterization of a human foamy virus 170-kilodalton Env-Bet fusion protein generated by alternative splicing.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- Unusual Fusion Proteins of HIV-1.Frontiers in microbiology · 2016Review
- Identification and functional characterization of Bet protein as a negative regulator of BFV3026 replication.Virus genes · 2014Article
- Review
- Foamy virus for efficient gene transfer in regeneration studies.BMC developmental biology · 2013Article
- Genetic characterization of simian foamy viruses infecting humans.Journal of virology · 2012Article
- Differential pH-dependent cellular uptake pathways among foamy viruses elucidated using dual-colored fluorescent particles.Retrovirology · 2012Article
- Prototype foamy virus gag nuclear localization: a novel pathway among retroviruses.Journal of virology · 2011Article
- Orthoretroviral-like prototype foamy virus Gag-Pol expression is compatible with viral replication.Retrovirology · 2011Article
- Novel functions of prototype foamy virus Gag glycine- arginine-rich boxes in reverse transcription and particle morphogenesis.Journal of virology · 2011Article
- Analysis of prototype foamy virus particle-host cell interaction with autofluorescent retroviral particles.Retrovirology · 2010Article
- Subviral particle release determinants of prototype foamy virus.Journal of virology · 2008Article
- Correct capsid assembly mediated by a conserved YXXLGL motif in prototype foamy virus Gag is essential for infectivity and reverse transcription of the viral genome.Journal of virology · 2007Article
- Restriction of foamy viruses by APOBEC cytidine deaminases.Journal of virology · 2006Article
- Ubiquitination of the prototype foamy virus envelope glycoprotein leader peptide regulates subviral particle release.Journal of virology · 2005Article
- N-terminal Gag domain required for foamy virus particle assembly and export.Journal of virology · 2005Article
- Analysis and function of prototype foamy virus envelope N glycosylation.Journal of virology · 2005Article
- Characterization of prototype foamy virus gag late assembly domain motifs and their role in particle egress and infectivity.Journal of virology · 2005Article
- Prototype foamy virus envelope glycoprotein leader peptide processing is mediated by a furin-like cellular protease, but cleavage is not essential for viral infectivity.Journal of virology · 2004Article
- Retrotransposition and cell-to-cell transfer of foamy viruses.Journal of virology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primate foamy viruses (FVs) express, in addition to the 130-kDa envelope protein, a 170-kDa glycoprotein, which reacts with antisera specific for the envelope and Bel proteins. We determined the exact nature of this 170-kDa glycoprotein by using the molecularly cloned human FV (HFV). Radioimmunoprecipitation analysis of 293T cells transfected with appropriate expression constructs by using antisera specific for the HFV Env, Bel1, and Bel2 proteins, as well as reverse transcription-PCR analysis of HFV-infected cells, demonstrated that this protein is an Env-Bet fusion protein that is secreted into the supernatant. However, it is only loosely associated, or not associated, with viral particles. gp170 is generated by an alternatively spliced Env mRNA using a splice donor and splice acceptor pair localized within the env open reading frame (ORF), which is normally used to generate Bell and Bet transcripts derived from the internal promoter within the env ORF. gp170 is expressed at a level 30 to 50% of the Env precursor gp130. However, it alone does not confer infectivity to HFV particles, because capsids derived from proviruses expressing only the gp170 were not released into the supernatant. In contrast, viruses derived from proviral clones deficient in gp170 expression showed similar in vitro infectivity and replication kinetics to wild-type virus. Furthermore, both types of viruses were inactivated to a similar extent by neutralizing sera, indicating that shedding of gp170 probably does not affect the humoral immune response in the infected host.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.