ArticleGenes & development1998
pX, the HBV-encoded coactivator, suppresses the phenotypes of TBP and TAFII250 mutants.
Article in Genes & development, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Structural and biochemical analysis of Bcl-2 interaction with the hepatitis B virus protein HBx.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Heterogeneous nuclear ribonucleoprotein R enhances transcription from the naturally configured c-fos promoter in vitro.The Journal of biological chemistry · 2009Article
- Cytochrome C oxidase III interacts with hepatitis B virus X protein in vivo by yeast two-hybrid system.World journal of gastroenterology · 2004Article
- Direct interaction of NRSF with TBP: chromatin reorganization and core promoter repression for neuron-specific gene transcription.Nucleic acids research · 2004Article
- Expression of nuclear factor-kappa B in hepatocellular carcinoma and its relation with the X protein of hepatitis B virus.World journal of gastroenterology · 2001Article
- Hepatitis B virus HBx protein activation of cyclin A-cyclin-dependent kinase 2 complexes and G1 transit via a Src kinase pathway.Journal of virology · 2001Article
- CREB/ATF-dependent repression of cyclin a by human T-cell leukemia virus type 1 Tax protein.Journal of virology · 2001Article
- A composite polyadenylation signal with TATA box function.Molecular and cellular biology · 2000Article
- HBV transcription repression in response to genotoxic stress is p53-dependent and abrogated by pX.Oncogene · 1999Article
- Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha.Molecular and cellular biology · 1999Article
- Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATA-binding protein.Molecular and cellular biology · 1998Article
- Hepatitis B virus pX targets TFIIB in transcription coactivation.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis B virus (HBV) infects humans and causes a wide range of clinical manifestations, from acute hepatitis to hepatocellular carcinoma (HCC). The HBV genome contains multiple promoters with gene expression regulated predominantly by the cellular transcription initiation machinery. Accordingly, the HBV-encoded pX, the only known viral regulator, is a potent transcription coactivator. We investigated the relationship between pX and cellular coactivators. We show that pX restores wild-type activity to inactive TBPAS mutants with poor TAFII250 and activator-binding activity. This pX-mediated recovery, however, is not obtained with inactive TBPAS mutants in binding of other general transcription factors. Remarkably, ts13, a cell line temperature sensitive for TAFII250 function, exhibiting growth arrest and apoptosis at the restrictive temperature, is rescued partially by pX expression, thus generating a pX-dependent cell growth. Collectively, our results suggest that pX suppresses some of the phenotypes of TBP and TAFII250 mutations, implying that pX circumvents the need for a holo-TFIID complex for transcription activation to proceed.
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