ArticleThe Journal of cell biology1998
Modulation of beta1A integrin functions by tyrosine residues in the beta1 cytoplasmic domain.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 107 citations in OpenAlex.
- α(M)β(2) integrin-mediated adhesion and motility of IL-5-stimulated eosinophils on periostin.American journal of respiratory cell and molecular biology · 2013Trial
- Effects of fluoroquinolone antibiotics on extracellular matrix-related phenotypes in tendon cells.Scientific reports · 2026Article
- The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells.The Journal of biological chemistry · 2021Article
- Transcription factor scleraxis vitally contributes to progenitor lineage direction in wound healing of adult tendon in mice.The Journal of biological chemistry · 2018Article
- Protein 4.1G Regulates Cell Adhesion, Spreading, and Migration of Mouse Embryonic Fibroblasts through the β1 Integrin Pathway.The Journal of biological chemistry · 2016Article
- The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoA.Molecular biology of the cell · 2015Article
- Contributions of the integrin β1 tail to cell adhesive forces.Experimental cell research · 2015Article
- Integrin inactivators: balancing cellular functions in vitro and in vivo.Nature reviews. Molecular cell biology · 2013Review
- Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms.Biology of reproduction · 2013Article
- Phosphatase of regenerating liver-3 directly interacts with integrin β1 and regulates its phosphorylation at tyrosine 783.BMC biochemistry · 2012Article
- β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins.Molecular and cellular biology · 2012Article
- Beta1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Identification of integrin beta subunit mutations that alter affinity for extracellular matrix ligand.The Journal of biological chemistry · 2011Article
- Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition.The Journal of cell biology · 2011Article
- β1 integrins regulate fibroblast chemotaxis through control of N-WASP stability.The EMBO journal · 2011Article
- p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration.The Journal of biological chemistry · 2010Article
- Analysis of conserved residues in the betapat-3 cytoplasmic tail reveals important functions of integrin in multiple tissues.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.The Journal of biological chemistry · 2009Article
- The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.The EMBO journal · 2009Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
beta1A integrin subunits with point mutations of the cytoplasmic domain were expressed in fibroblasts derived from beta1-null stem cells. beta1A in which one or both of the tyrosines of the two NPXY motifs (Y783, Y795) were changed to phenylalanines formed active alpha5 beta1 and alpha6 beta1 integrins that mediated cell adhesion and supported assembly of fibronectin. Mutation of the proline in either motif (P781, P793) to an alanine or of a threonine in the inter-motif sequence (T788) to a proline resulted in poorly expressed, inactive beta1A. Y783,795F cells developed numerous fine focal contacts and exhibited motility on a surface. When compared with cells expressing wild-type beta1A or beta1A with the D759A activating mutation of a conserved membrane-proximal aspartate, Y783, 795F cells had impaired ability to transverse filters in chemotaxis assays. Analysis of cells expressing beta1A with single Tyr to Phe substitutions indicated that both Y783 and Y795 are important for directed migration. Actin-containing microfilaments of Y783,795F cells were shorter and more peripheral than microfilaments of cells expressing wild-type beta1A. These results indicate that change of the phenol side chains in the NPXY motifs to phenyl groups (which cannot be phosphorylated) has major effects on the organization of focal contacts and cytoskeleton and on directed cell motility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.