ArticleThe Journal of cell biology1998
Human autoantibodies reveal titin as a chromosomal protein.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 122 citations in OpenAlex.
- Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane-Fly Spermatocytes.Cytoskeleton (Hoboken, N.J.) · 2026Article
- Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.Scientific reports · 2024Article
- Predictive modeling of gene mutations for the survival outcomes of epithelial ovarian cancer patients.PloS one · 2024Article
- Cardiac Sarcoidosis and a Likely PathogenicJACC. Case reports · 2023Article
- COVID-19 vaccination-related autoimmune hepatitis-a perspective.Frontiers in pharmacology · 2023Article
- Systemic sclerosis in a patient with muscle dystrophy.BMJ case reports · 2022Article
- Comprehensive Cohort Analysis of Mutational Spectrum in Early Onset Breast Cancer Patients.Cancers · 2020Article
- Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function.Circulation · 2019Article
- Nuclear connectin novex-3 promotes proliferation of hypoxic foetal cardiomyocytes.Scientific reports · 2018Article
- The purplish bifurcate mussel Mytilisepta virgata gene expression atlas reveals a remarkable tissue functional specialization.BMC genomics · 2017Article
- GermlineNPJ genomic medicine · 2017Article
- Clonal hematopoiesis in patients with dyskeratosis congenita.American journal of hematology · 2016Article
- Drosophila FoxL1 non-autonomously coordinates organ placement during embryonic development.Developmental biology · 2016Article
- Actin, actin-binding proteins, and actin-related proteins in the nucleus.Histochemistry and cell biology · 2016Review
- Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population.BMC cancer · 2016Article
- Article
- Repeat or not repeat?--Statistical validation of tandem repeat prediction in genomic sequences.Nucleic acids research · 2012Article
- Evolution: functional evolution of nuclear structure.The Journal of cell biology · 2011Review
- The nucleoskeleton as a genome-associated dynamic 'network of networks'.Nature reviews. Molecular cell biology · 2011Review
- Proteomic signatures in plasma during early acute renal allograft rejection.Molecular & cellular proteomics : MCP · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assembly of the higher-order structure of mitotic chromosomes is a prerequisite for proper chromosome condensation, segregation and integrity. Understanding the details of this process has been limited because very few proteins involved in the assembly of chromosome structure have been discovered. Using a human autoimmune scleroderma serum that identifies a chromosomal protein in human cells and Drosophila embryos, we cloned the corresponding Drosophila gene that encodes the homologue of vertebrate titin based on protein size, sequence similarity, developmental expression and subcellular localization. Titin is a giant sarcomeric protein responsible for the elasticity of striated muscle that may also function as a molecular scaffold for myofibrillar assembly. Molecular analysis and immunostaining with antibodies to multiple titin epitopes indicates that the chromosomal and muscle forms of titin may vary in their NH2 termini. The identification of titin as a chromosomal component provides a molecular basis for chromosome structure and elasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.