ArticleJapanese journal of cancer research : Gann1998
Induction of squamous cell carcinomas in the salivary glands of rats by potassium iodide.
Article in Japanese journal of cancer research : Gann, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Correlation of Clinical and Histopathological Features of Salivary Pleomorphic Adenoma.Journal of dentistry (Shiraz, Iran) · 2023Article
- Pleomorphic Adenoma with Extensive Squamous and Adipocytic Metaplasia Mimicking as Low Grade Mucoepidermoid Carcinoma on FNAC.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Pleomorphic Adenoma in the Lower Lip: A Case Report and a Review.European journal of dentistry · 2019Article
- Parenchymal changes of salivary glands adjacent to a variety of salivary gland disorders.International journal of clinical and experimental pathology · 2019Article
- Squamous Metaplasia in Pleomorphic Adenoma: A Diagnostic and Prognostic Enigma.Journal of pathology and translational medicine · 2018Article
- Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model.BioMed research international · 2017Article
- Minor Salivary Gland Changes in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma - A Histopathological Study.Journal of clinical and diagnostic research : JCDR · 2016Article
- Nonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and Mouse.Journal of toxicologic pathology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a 2-year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high-dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non-genotoxic, proliferation-dependent mechanism.
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Registered trials
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