ArticleThe Journal of experimental medicine1998
CD40 ligand is not essential for induction of type 1 cytokine responses or protective immunity after primary or secondary infection with histoplasma capsulatum.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 62 citations in OpenAlex.
- Harnessing the Immune Response to Fungal Pathogens for Vaccine Development.Annual review of microbiology · 2022Review
- Dual roles of CD40 on microbial containment and the development of immunopathology in response to persistent fungal infection in the lung.The American journal of pathology · 2010Article
- Methamphetamine enhances histoplasmosis by immunosuppression of the host.The Journal of infectious diseases · 2009Article
- Immunogenicity of human mesenchymal stem cells in HLA-class I-restricted T-cell responses against viral or tumor-associated antigens.Stem cells (Dayton, Ohio) · 2008Article
- The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- In the absence of CD154, administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma mansoni.Infection and immunity · 2007Article
- Interleukin-1 and host control of pulmonary histoplasmosis.The Journal of infectious diseases · 2006Article
- Pulmonary V beta 4+ T cells from Histoplasma capsulatum-infected mice respond to a homologue of Sec31 that confers a protective response.The Journal of infectious diseases · 2006Article
- T cells require tumor necrosis factor-alpha to provide protective immunity in mice infected with Histoplasma capsulatum.The Journal of infectious diseases · 2006Article
- Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum.The Journal of clinical investigation · 2005Article
- Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatum.Infection and immunity · 2002Article
- Discordance between T-cell receptor expression and effector function in mice infected with Histoplasma capsulatum.Infection and immunity · 2002Article
- Mycobacterium bovis BCG-induced granuloma formation depends on gamma interferon and CD40 ligand but does not require CD28.Infection and immunity · 2001Article
- Recombinant murine granulocyte-macrophage colony-stimulating factor modulates the course of pulmonary histoplasmosis in immunocompetent and immunodeficient mice.Antimicrobial agents and chemotherapy · 2000Article
- Depressed CD40 ligand expression contributes to reduced gamma interferon production in human tuberculosis.Infection and immunity · 2000Article
- Dendritic cells: immunological sentinels with a central role in health and disease.Immunology and cell biology · 2000Review
- The CD40/CD40 ligand interaction is required for resistance to toxoplasmic encephalitis.Infection and immunity · 2000Article
- Acquired, but not innate, immune responses to Streptococcus pneumoniae are compromised by neutralization of CD40L.Infection and immunity · 2000Article
- CD40-CD40 ligand interactions augment survival of normal mice, but not CD40 ligand knockout mice, challenged orally with Salmonella dublin.Infection and immunity · 1999Article
- CD40 ligation prevents Trypanosoma cruzi infection through interleukin-12 upregulation.Infection and immunity · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The induction of type 1 immune responses (interleukin [IL]-12, interferon [IFN]-gamma) has been shown to be important in mediating protection against many intracellular infections including Histoplasma capsulatum. Costimulatory molecules such as CD40 ligand (CD40L) have been shown to be a central regulator of type 1 responses in vivo. To study the role of CD40L in mediating protection against infection with H. capsulatum, CD40L-deficient (CD40L-/-) and CD40L+/+ mice were infected with H. capsulatum and assessed for various parameters. After a lethal challenge of H. capsulatum, CD40L-/- mice were not substantially different from CD40L+/+ mice in terms of mortality, fungal burden, or production of IFN-gamma, IL-12, nitric oxide, or tumor necrosis factor alpha. Moreover, CD40L-/- mice treated with anti-IFN-gamma or anti-IL-12 at the time of infection had accelerated mortality, providing further evidence that IL-12 and IFN-gamma are produced in vivo in the absence of CD40L. In addition, CD40L-/- mice infected with a sublethal dose of H. capsulatum survived infection, whereas all mice infected with the same dose and treated with anti-IFN-gamma had accelerated mortality, demonstrating that IFN-gamma but not CD40L was essential for primary immunity to H. capsulatum infection. Interestingly, depletion of either CD4+ or CD8+ T cells resulted in accelerated mortality in CD40L-/- mice, suggesting a critical role for these cells in response to infection. Finally, CD40L-/- mice initially infected with a sublethal dose of H. capsulatum were protected from secondary infection with a lethal dose of H. capsulatum, demonstrating that CD40L is not required for the maintenance of memory immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.