ArticleThe Journal of experimental medicine1998
Impaired interleukin 4 signaling in T helper type 1 cells.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 91 citations in OpenAlex.
- Potential Natural Biomolecules Targeting JAK/STAT/SOCS Signaling in the Management of Atopic Dermatitis.Molecules (Basel, Switzerland) · 2022Review
- A New IRF-1-Driven Apoptotic Pathway Triggered by IL-4/IL-13 Kills Neonatal Th1 Cells and Weakens Protection against Viral Infection.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Tregitope-linked Refined Allergen Vaccines for Immunotherapy in Cockroach Allergy.Scientific reports · 2018Article
- IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- On the Role IL-4/IL-13 Heteroreceptor Plays in Regulation of Type 1 Diabetes.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Neonatal Basophils Stifle the Function of Early-Life Dendritic Cells To Curtail Th1 Immunity in Newborn Mice.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- IFN-γ suppresses permissive chromatin remodeling in the regulatory region of the Il4 gene.Cytokine · 2013Article
- Sensitivity and resistance to regulation by IL-4 during Th17 maturation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Regulation of immunity at tissue sites of inflammation.Immunologic research · 2009Review
- Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells.Trends in immunology · 2009Review
- A continuous T-bet expression is required to silence the interleukin-4-producing potential in T helper type 1 cells.Immunology · 2009Article
- IL-23 promotes maintenance but not commitment to the Th17 lineage.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity.The Journal of experimental medicine · 2008Article
- Th2 cell therapy of established acute graft-versus-host disease requires IL-4 and IL-10 and is abrogated by IL-2 or host-type antigen-presenting cells.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2008Article
- The key regulators of adult T helper cell responses, STAT6 and T-bet, are established in early life in mice.European journal of immunology · 2006Article
- Suppressor of cytokine signaling 3 (SOCS3) in Th2 cells evokes Th2 cytokines, IgE, and eosinophilia.Current allergy and asthma reports · 2006Review
- Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12.The Journal of experimental medicine · 2002Article
- Influence of parasite load on the ability of type 1 T cells to control Leishmania major infection.Infection and immunity · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cluster of differentation (CD)4+ T helper cells (Th)1s fail to produce interleukin (IL)-4. Even if restimulated in the presence of IL-4, a condition that induces IL-4-producing capacity in naive CD4+ T cells, Th1s fail to become IL-4 producers. We report that Th1 cells have a major impairment in IL-4 signaling. When compared to both Th2s and naive T cells, they display a striking diminution in phosphorylation of Stat6. They also show reduced phosphorylation of Janus kinase (JAK)-3 and insulin receptor substrate (IRS)-2 when compared to Th2s. Stat6 and JAK-3 are present in equivalent amounts in Th1s and Th2s, but IRS-2 protein levels are much lower in Th1s than in Th2s. Altered sensitivity to IL-4, the major inducer of the Th2 phenotype, may explain the stability of the Th1 state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.