ArticleThe Journal of experimental medicine1998
The normal counterpart of IgD myeloma cells in germinal center displays extensively mutated IgVH gene, Cmu-Cdelta switch, and lambda light chain expression.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 137 citations in OpenAlex.
- Characterization of immunoglobulin loci inNAR genomics and bioinformatics · 2026Article
- Immunoglobulin heavy chain locus duplication in bats.Science advances · 2026Article
- IgT and IgD dominance in the teleost central nervous system.Frontiers in immunology · 2025Article
- CCR7A defines a subpopulation of IgDFrontiers in immunology · 2025Article
- Immunoglobulin class-switch recombination: Mechanism, regulation, and related diseases.MedComm · 2024Review
- Teleost IgDiScience · 2023Article
- CD27 on human memory B cells-more than just a surface marker.Clinical and experimental immunology · 2023Review
- Deep immune B and plasma cell repertoire in non-small cell lung cancer.Frontiers in immunology · 2023Article
- B cells defined by immunoglobulin isotypes.Clinical and experimental immunology · 2022Article
- A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing.Journal of experimental & clinical cancer research : CR · 2022Article
- Rad52 mediates class-switch DNA recombination to IgD.Nature communications · 2022Article
- Clinical characteristics and survival of patients with IgD multiple myeloma.Blood science (Baltimore, Md.) · 2021Article
- OMIP-068: High-Dimensional Characterization of Global and Antigen-Specific B Cells in Chronic Infection.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2020Article
- Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgMDevelopmental and comparative immunology · 2020Article
- Immunoglobulins or Antibodies: IMGTBiomedicines · 2020Review
- Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA.Nature reviews. Immunology · 2020Review
- Plasma cells, plasmablasts, and AIDHistochemistry and cell biology · 2020Article
- Systemic and Mucosal B and T Cell Responses Upon Mucosal Vaccination of Teleost Fish.Frontiers in immunology · 2020Review
- Type I Interferon Regulates the Survival and Functionality of B Cells in Rainbow Trout.Frontiers in immunology · 2020Article
- Teleost IgDCell reports · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human myeloma are incurable hematologic cancers of immunoglobulin-secreting plasma cells in bone marrow. Although malignant plasma cells can be almost eradicated from the patient's bone marrow by chemotherapy, drug-resistant myeloma precursor cells persist in an apparently cryptic compartment. Controversy exists as to whether myeloma precursor cells are hematopoietic stem cells, pre-B cells, germinal center (GC) B cells, circulating memory cells, or plasma blasts. This situation reflects what has been a general problem in cancer research for years: how to compare a tumor with its normal counterpart. Although several studies have demonstrated somatically mutated immunoglobulin variable region genes in multiple myeloma, it is unclear if myeloma cells are derived from GCs or post-GC memory B cells. Immunoglobulin (Ig)D-secreting myeloma have two unique immunoglobulin features, including a biased lambda light chain expression and a Cmu-Cdelta isotype switch. Using surface markers, we have previously isolated a population of surface IgM-IgD+CD38+ GC B cells that carry the most impressive somatic mutation in their IgV genes. Here we show that this population of GC B cells displays the two molecular features of IgD-secreting myeloma cells: a biased lambda light chain expression and a C&mu-Cdelta isotype switch. The demonstration of these peculiar GC B cells to differentiate into IgD-secreting plasma cells but not memory B cells both in vivo and in vitro suggests that IgD-secreting plasma and myeloma cells are derived from GCs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.