ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Neurolin, the goldfish homolog of DM-GRASP, is involved in retinal axon pathfinding to the optic disk.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Identification and enrichment of human retinal organoid-derived red/green cone-competent precursors with enhanced axon dynamics.Stem cell research & therapy · 2026Article
- Signaling - transcription interactions in mouse retinal ganglion cells early axon pathfinding -a literature review.Frontiers in ophthalmology · 2023Review
- To Stick or Not to Stick: The Multiple Roles of Cell Adhesion Molecules in Neural Circuit Assembly.Frontiers in neuroscience · 2022Review
- Trans-Axonal Signaling in Neural Circuit Wiring.International journal of molecular sciences · 2020Review
- F-spondin Is Essential for Maintaining Circadian Rhythms.Frontiers in neural circuits · 2018Article
- Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The role of cell adhesion molecules in visual circuit formation: from neurite outgrowth to maps and synaptic specificity.Developmental neurobiology · 2015Review
- Connecting the retina to the brain.ASN neuro · 2014Review
- Development of the retina and optic pathway.Vision research · 2011Review
- ALCAM regulates mediolateral retinotopic mapping in the superior colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Robo2 is required for Slit-mediated intraretinal axon guidance.Developmental biology · 2009Article
- Pathfinding in a large vertebrate axon tract: isotypic interactions guide retinotectal axons at multiple choice points.Development (Cambridge, England) · 2008Article
- Intraretinal projection of retinal ganglion cell axons as a model system for studying axon navigation.Brain research · 2008Review
- Slit proteins regulate distinct aspects of retinal ganglion cell axon guidance within dorsal and ventral retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Sonic hedgehog has a dual effect on the growth of retinal ganglion axons depending on its concentration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Connecting the eye to the brain: the molecular basis of ganglion cell axon guidance.The British journal of ophthalmology · 2003Review
- The L1 cell adhesion molecule is essential for topographic mapping of retinal axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- A purine-sensitive pathway regulates multiple genes involved in axon regeneration in goldfish retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The receptor tyrosine phosphatase CRYPalpha promotes intraretinal axon growth.The Journal of cell biology · 1999Article
- Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP.The Journal of cell biology · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Young axons of new retinal ganglion cells (RGCs) in the continuously growing goldfish retina fasciculate with one another and their immediate forerunners on their path toward the optic disk and along the optic nerve. They express the immunoglobulin superfamily cell adhesion molecules (CAMs) neurolin (DM-GRASP) and the L1-like E587 antigen. Repeated injections of Fab fragments from polyclonal antisera against neurolin (neurolin Fabs) into the eye of 3. 4-cm-long and rapidly growing goldfish caused highly aberrant pathways of young RGC axon subfascicles in the dorsal retina. Many axons grew in circles and failed to reach the optic disk. In contrast, E587 Fabs, used in parallel experiments, disrupted the fascicles but did not interfere with the disk-directed growth. Neurolin Fabs also disturbed axonal fasciculation in vivo as well as in vitro but less severely than E587 Fabs. Coinjections of both Fabs increased defasciculation of the dorsal axons in both aberrant and disk-directed routes. They also disrupted the order of young RGC axons in the optic nerve more severely than E587 Fabs alone. This demonstrates that the development of tight and orderly fascicles in the dorsal retina and in the optic nerve requires both E587 antigen and neurolin. More importantly, our results suggest an involvement of neurolin in RGC axonal guidance from the retinal periphery to the optic disk. Because disrupted fascicles and errant axon routes were found only in the dorsal retinal half, a cooperation with so-called positional markers may be conceived.
Indexed as
Identifiers
9547244PMC6792637W2125912880What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.